8VE0
Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation
Summary for 8VE0
Entry DOI | 10.2210/pdb8ve0/pdb |
EMDB information | 43160 |
Descriptor | Transthyretin, 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (2 entities in total) |
Functional Keywords | amyloidosis, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 56256.98 |
Authors | Basanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Tsai, F.J.,Wu, M.,Kelly, J.W.,Lander, G.C. (deposition date: 2023-12-18, release date: 2024-01-31, Last modification date: 2024-03-13) |
Primary citation | Basanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Powers, E.T.,Tsai, F.J.,Wu, M.,Hansel-Harris, A.,Chen, J.,Forli, S.,Kelly, J.W.,Lander, G.C. The conformational landscape of human transthyretin revealed by cryo-EM To Be Published, |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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