4BGL
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![BU of 4bgl by Molmil](/molmil-images/mine/4bgl) | Superoxide reductase (Neelaredoxin) from Archaeoglobus fulgidus | Descriptor: | FE (III) ION, GLYCEROL, SUPEROXIDE REDUCTASE | Authors: | Bandeiras, T.M, Rodrigues, J.V, Sousa, C.M, Barradas, A.R, Pinho, F.G, Pinto, A.F, Teixeira, M, Matias, P.M, Romao, C.V. | Deposit date: | 2013-03-27 | Release date: | 2014-04-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Superoxide Reductase from Giardia Intestinalis: Structural Characterization of the First Sor from a Eukaryotic Organism Shows an Iron Centre that is Highly Sensitive to Photoreduction Acta Crystallogr.,Sect.D, 71, 2015
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1T2F
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![BU of 1t2f by Molmil](/molmil-images/mine/1t2f) | Human B lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid | Descriptor: | 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | Deposit date: | 2004-04-21 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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4C4U
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![BU of 4c4u by Molmil](/molmil-images/mine/4c4u) | Superoxide reductase (Neelaredoxin) from Archaeoglobus fulgidus E12Q mutant in the reduced form | Descriptor: | FE (II) ION, SUPEROXIDE REDUCTASE | Authors: | Bandeiras, T.M, Rodrigues, J.V, Sousa, C.M, Barradas, A.R, Pinho, F.G, Pinto, A.F, Teixeira, M, Matias, P.M, Romao, C.V. | Deposit date: | 2013-09-09 | Release date: | 2014-08-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.583 Å) | Cite: | Understanding the Role of Key Residues in the Superoxide Reductase Molecular Mechanism, Exploring Archaeoglobus Fulgidus Sor Structure To be Published
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1R3T
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![BU of 1r3t by Molmil](/molmil-images/mine/1r3t) | Uroporphyrinogen Decarboxylase single mutant D86G in complex with coproporphyrinogen-III | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen Decarboxylase | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | Deposit date: | 2003-10-03 | Release date: | 2003-12-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase Embo J., 22, 2003
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1R3W
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![BU of 1r3w by Molmil](/molmil-images/mine/1r3w) | Uroporphyrinogen Decarboxylase Y164F mutant in complex with coproporphyrinogen-III | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen Decarboxylase | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | Deposit date: | 2003-10-03 | Release date: | 2003-12-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase Embo J., 22, 2003
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1R3S
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![BU of 1r3s by Molmil](/molmil-images/mine/1r3s) | Uroporphyrinogen Decarboxylase single mutant D86G in complex with coproporphyrinogen-I | Descriptor: | COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | Deposit date: | 2003-10-03 | Release date: | 2003-12-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase Embo J., 22, 2003
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1R3Q
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![BU of 1r3q by Molmil](/molmil-images/mine/1r3q) | Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I | Descriptor: | CARBON DIOXIDE, COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | Deposit date: | 2003-10-03 | Release date: | 2003-12-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase Embo J., 22, 2003
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4B0I
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![BU of 4b0i by Molmil](/molmil-images/mine/4b0i) | Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) mutant (H70N) from Pseudomonas aeruginosa in complex with 3-hydroxydecanoyl-N-acetyl cysteamine | Descriptor: | 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, S-[2-(acetylamino)ethyl] (3R)-3-hydroxydecanethioate | Authors: | Moynie, L, McMahon, S.A, Leckie, S.M, Duthie, F.G, Koehnke, A, Naismith, J.H. | Deposit date: | 2012-07-02 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas Aeruginosa J.Mol.Biol., 425, 2013
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4B8U
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![BU of 4b8u by Molmil](/molmil-images/mine/4b8u) | Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N- isobutyl-2-(5-(2-thienyl)-1,2-oxazol-3-yl-)methoxy)acetamide | Descriptor: | 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-isobutyl-2-{[5-(thiophen-2-yl)-1,2-oxazol-3-yl]methoxy}acetamide, SULFATE ION | Authors: | Moynie, L, McMahon, S.A, Duthie, F.G, Brenk, R, Naismith, J.H. | Deposit date: | 2012-08-30 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa. J.Mol.Biol., 425, 2013
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1URO
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![BU of 1uro by Molmil](/molmil-images/mine/1uro) | UROPORPHYRINOGEN DECARBOXYLASE | Descriptor: | BETA-MERCAPTOETHANOL, PROTEIN (UROPORPHYRINOGEN DECARBOXYLASE) | Authors: | Whitby, F.G, Phillips, J.D, Kushner, J.P, Hill, C.P. | Deposit date: | 1998-08-21 | Release date: | 1998-08-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human uroporphyrinogen decarboxylase. EMBO J., 17, 1998
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1T2E
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![BU of 1t2e by Molmil](/molmil-images/mine/1t2e) | Plasmodium falciparum lactate dehydrogenase S245A, A327P mutant complexed with NADH and oxamate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-lactate dehydrogenase, ... | Authors: | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | Deposit date: | 2004-04-21 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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4C4B
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![BU of 4c4b by Molmil](/molmil-images/mine/4c4b) | Superoxide reductase (Neelaredoxin) from Archaeoglobus fulgidus E12V in the reduced form | Descriptor: | 1,2-ETHANEDIOL, FE (II) ION, SUPEROXIDE REDUCTASE | Authors: | Bandeiras, T.M, Rodrigues, J.V, Sousa, C.M, Barradas, A.R, Pinho, F.G, Pinto, A.F, Teixeira, M, Matias, P.M, Romao, C.V. | Deposit date: | 2013-09-03 | Release date: | 2014-07-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Understanding the Role of Key Residues in the Superoxide Reductase Molecular Mechanism, Exploring Archaeoglobus Fulgidus Sor Structure To be Published
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1T26
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![BU of 1t26 by Molmil](/molmil-images/mine/1t26) | Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase | Authors: | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | Deposit date: | 2004-04-20 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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1T2C
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![BU of 1t2c by Molmil](/molmil-images/mine/1t2c) | Plasmodium falciparum lactate dehydrogenase complexed with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-lactate dehydrogenase | Authors: | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | Deposit date: | 2004-04-21 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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3EBU
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![BU of 3ebu by Molmil](/molmil-images/mine/3ebu) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-08-28 | Release date: | 2010-03-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3EIH
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![BU of 3eih by Molmil](/molmil-images/mine/3eih) | Crystal structure of S.cerevisiae Vps4 in the presence of ATPgammaS | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gonciarz, M.D, Whitby, F.G, Eckert, D.M, Kieffer, C, Heroux, A, Sundquist, W.I, Hill, C.P. | Deposit date: | 2008-09-15 | Release date: | 2008-09-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Biochemical and structural studies of yeast vps4 oligomerization. J.Mol.Biol., 384, 2008
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3EAW
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![BU of 3eaw by Molmil](/molmil-images/mine/3eaw) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-08-26 | Release date: | 2010-03-02 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3EJL
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![BU of 3ejl by Molmil](/molmil-images/mine/3ejl) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, PHOSPHATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-09-18 | Release date: | 2010-03-02 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3ED7
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![BU of 3ed7 by Molmil](/molmil-images/mine/3ed7) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-09-02 | Release date: | 2010-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3EIE
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![BU of 3eie by Molmil](/molmil-images/mine/3eie) | Crystal Structure of S.cerevisiae Vps4 in the SO4-bound state | Descriptor: | SULFATE ION, Vacuolar protein sorting-associated protein 4 | Authors: | Gonciarz, M.D, Whitby, F.G, Eckert, D.M, Kieffer, C, Heroux, A, Sundquist, W.I, Hill, C.P. | Deposit date: | 2008-09-15 | Release date: | 2008-09-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Biochemical and structural studies of yeast vps4 oligomerization. J.Mol.Biol., 384, 2008
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3EDW
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![BU of 3edw by Molmil](/molmil-images/mine/3edw) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-09-03 | Release date: | 2010-03-02 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3DEN
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![BU of 3den by Molmil](/molmil-images/mine/3den) | Structure of E. coli DHDPS mutant Y107W | Descriptor: | Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Pearce, F.G, Gerrard, J.A, Perugini, M.A, Jameson, G.B. | Deposit date: | 2008-06-10 | Release date: | 2008-11-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme Biochemistry, 47, 2008
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3EF9
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![BU of 3ef9 by Molmil](/molmil-images/mine/3ef9) | Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. | Deposit date: | 2008-09-08 | Release date: | 2010-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
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3GVV
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![BU of 3gvv by Molmil](/molmil-images/mine/3gvv) | Single-chain UROD Y164G (GY) mutation | Descriptor: | Uroporphyrinogen decarboxylase | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | Deposit date: | 2009-03-31 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen. J.Mol.Biol., 389, 2009
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3GW3
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![BU of 3gw3 by Molmil](/molmil-images/mine/3gw3) | human UROD mutant K297N | Descriptor: | Uroporphyrinogen decarboxylase | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | Deposit date: | 2009-03-31 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases. Cell Mol Biol (Noisy-le-grand), 55, 2009
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