3ED7
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Summary for 3ED7
| Entry DOI | 10.2210/pdb3ed7/pdb |
| Related | 1HW3 3EAW 3EBU 3EDW 3EF9 3EJL 3GG5 3GH0 3GH2 |
| Descriptor | Thymidylate synthase, SULFATE ION (3 entities in total) |
| Functional Keywords | transferase, methyltransferase, nucleotide biosynthesis |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34005.93 |
| Authors | Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H. (deposition date: 2008-09-02, release date: 2010-03-02, Last modification date: 2024-02-21) |
| Primary citation | Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H.,Lebioda, L. Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49:2475-2482, 2010 Cited by PubMed: 20151707DOI: 10.1021/bi901457e PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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