3EBU

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

Summary for 3EBU

• Entry DOI: 10.2210/pdb3ebu/pdb
• Related: 1HW3 1YPV 3EAW 3ED7 3EDW 3EF9 3EJL 3GG5 3GH0 3GH2
• Descriptor: Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, methyltransferase, nucleotide biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 1
• Total formula weight: 36343.52

Authors

Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H. (deposition date: 2008-08-28, release date: 2010-03-02, Last modification date: 2023-08-30)

• Primary citation: Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H.,Lebioda, L.; Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .; Biochemistry, 49:2475-2482, 2010; PubMed: 20151707; DOI: 10.1021/bi901457e

Experimental method

X-RAY DIFFRACTION (2.05 Å)