3EJL
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Summary for 3EJL
Entry DOI | 10.2210/pdb3ejl/pdb |
Related | 1HW3 1YPV 3EAW 3EBU 3ED7 3EDW 3EF9 3GG5 3GH0 3GH2 |
Descriptor | Thymidylate synthase, PHOSPHATE ION, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (4 entities in total) |
Functional Keywords | transferase, methyltransferase, nucleotide biosynthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 4 |
Total formula weight | 143855.01 |
Authors | Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H. (deposition date: 2008-09-18, release date: 2010-03-02, Last modification date: 2021-10-20) |
Primary citation | Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H.,Lebioda, L. Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49:2475-2482, 2010 Cited by PubMed: 20151707DOI: 10.1021/bi901457e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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