4B0I

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) mutant (H70N) from Pseudomonas aeruginosa in complex with 3-hydroxydecanoyl-N-acetyl cysteamine

Summary for 4B0I

Entry DOI	10.2210/pdb4b0i/pdb
Related	4B0B 4B0C 4B0J 4B8U 4FQ9
Descriptor	3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, S-[2-(acetylamino)ethyl] (3R)-3-hydroxydecanethioate (3 entities in total)
Functional Keywords	lyase, fatty acid biosynthesis, bacterial virulence, drug discovery
Biological source	PSEUDOMONAS AERUGINOSA
Cellular location	Cytoplasm (By similarity): O33877
Total number of polymer chains	5
Total formula weight	95169.61
Authors	Moynie, L.,McMahon, S.A.,Leckie, S.M.,Duthie, F.G.,Koehnke, A.,Naismith, J.H. (deposition date: 2012-07-02, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citation	Moynie, L.,Leckie, S.M.,Mcmahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H. Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas Aeruginosa J.Mol.Biol., 425:365-, 2013 Cited by PubMed: 23174186 DOI: 10.1016/J.JMB.2012.11.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation