3GVV

Single-chain UROD Y164G (GY) mutation

Summary for 3GVV

Entry DOI	10.2210/pdb3gvv/pdb
Related	1uro 3GVQ 3GVR 3GVW
Descriptor	Uroporphyrinogen decarboxylase (2 entities in total)
Functional Keywords	uroporphyrinogen, decarboxylase, lyase, heme biosynthesis, acetylation, cytoplasm, disease mutation, phosphoprotein, porphyrin biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P06132
Total number of polymer chains	1
Total formula weight	40847.77
Authors	Hill, C.P.,Phillips, J.D.,Whitby, F.G.,Warby, C.,Kushner, J.P. (deposition date: 2009-03-31, release date: 2009-07-07, Last modification date: 2024-02-21)
Primary citation	Phillips, J.D.,Warby, C.A.,Whitby, F.G.,Kushner, J.P.,Hill, C.P. Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen. J.Mol.Biol., 389:306-314, 2009 Cited by PubMed: 19362562 DOI: 10.1016/j.jmb.2009.04.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation