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PDB: 28 件
4ZOK
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BU of 4zok by Molmil
Methylsulfonyl-containing inhibitor bound in the substrate capture site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid, Anthranilate phosphoribosyltransferase, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-06
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZOJ
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BU of 4zoj by Molmil
Methylsulfanyl-containing inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4-methyl-2-{[2-methyl-6-(methylsulfanyl)phenyl]amino}benzoic acid, Anthranilate phosphoribosyltransferase, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-06
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZOF
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BU of 4zof by Molmil
Lobenzarit-like inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxy-5-nitrophenyl)amino]-3-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-06
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZTV
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BU of 4ztv by Molmil
Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP
分子名称: 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase
著者Evans, G.L, Eom, J, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-15
公開日2016-05-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.
To be Published
5BO3
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BU of 5bo3 by Molmil
Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 2-[(2-carboxyphenyl)amino]-5-(4-phosphonobutoxy)benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-27
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5BO2
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BU of 5bo2 by Molmil
Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 2-[(2-carboxyphenyl)amino]-5-(3-phosphonopropoxy)benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-27
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5BNE
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BU of 5bne by Molmil
Bianthranilate-like inhibitor with 6 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 2-[(2-carboxyphenyl)amino]-5-[(5-phosphonopentyl)oxy]benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-05-26
公開日2016-05-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5C1R
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BU of 5c1r by Molmil
Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD)
分子名称: 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-06-15
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP.
To Be Published
5C2L
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BU of 5c2l by Molmil
Magnesium soaked into the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: Anthranilate phosphoribosyltransferase, IMIDAZOLE, MAGNESIUM ION
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-06-16
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.009 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
5C7S
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BU of 5c7s by Molmil
PRPP complexed with two Mn2+ in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MANGANESE (II) ION
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-06-24
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
5BYT
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BU of 5byt by Molmil
PRPP complexed with a single Mg in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-06-11
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
4YI7
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BU of 4yi7 by Molmil
Anthranilate bound at active site of anthranilate phosphoribosyl transferase from Acinetobacter (AnPRT; TrpD)
分子名称: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase
著者Evans, G.L, Newton, M.S, Norris, G.E, Patrick, W.M.
登録日2015-02-28
公開日2015-09-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.853 Å)
主引用文献Substrate inhibition of protein in tryptophan biosynthesis pathway redirects flux to aromatic catabolism in Acinetobacter baylyi ADP1.
To Be Published
3L21
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BU of 3l21 by Molmil
The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (DAPA, RV2753C) from Mycobacterium Tuberculosis - DHDPS-A204R
分子名称: ACETATE ION, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Evans, G.L, Schuldt, L, Jamerson, G.B, Devenish, S.R, Weiss, M.S, Gerrard, J.A.
登録日2009-12-14
公開日2010-12-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A dimeric mutant of DHDPS from Mycobacterium tuberculosis
To be Published
4GKM
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BU of 4gkm by Molmil
Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (AnPRT; trpD)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2012-08-13
公開日2013-08-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6683 Å)
主引用文献Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4GIU
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BU of 4giu by Molmil
Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (AnPRT; trpD).
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2012-08-09
公開日2013-08-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.667 Å)
主引用文献Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4IJ1
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BU of 4ij1 by Molmil
Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates.
分子名称: 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2012-12-20
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4M0R
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BU of 4m0r by Molmil
Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).
分子名称: 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, Anthranilate phosphoribosyltransferase, DIMETHYL SULFOXIDE, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2013-08-02
公開日2014-05-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
8UCY
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BU of 8ucy by Molmil
Sterile Alpha Motif (SAM) domain from Tric1, Arabidopsis thaliana
分子名称: CHLORIDE ION, Chloroplastic import inner membrane translocase subunit HP30-1
著者Olasz, B, Vrielink, A, Evans, G.L.
登録日2023-09-27
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Structural analysis of the SAM domain of the Arabidopsis mitochondrial tRNA import receptor.
J.Biol.Chem., 300, 2024
4X58
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BU of 4x58 by Molmil
Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ...
著者Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
登録日2014-12-04
公開日2015-11-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X59
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BU of 4x59 by Molmil
Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
著者Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
登録日2014-12-04
公開日2015-11-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5E
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BU of 4x5e by Molmil
Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound
分子名称: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
著者Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
登録日2014-12-05
公開日2015-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
6HK0
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BU of 6hk0 by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S pore mutant (F247S) with alternate M4 conformation.
分子名称: Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE
著者Nury, H, Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
登録日2018-09-04
公開日2019-10-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HJX
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BU of 6hjx by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE, ...
著者Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
登録日2018-09-04
公開日2019-10-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HJY
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BU of 6hjy by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72
分子名称: Cys-loop ligand-gated ion channel, nanobody 72
著者Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
登録日2018-09-04
公開日2019-10-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
5CWA
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BU of 5cwa by Molmil
Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound
分子名称: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Anthranilate synthase component 1, GLYCEROL, ...
著者Johnston, J.M, Bashiri, G, Evans, G.L, Lott, J.S, Baker, E.N.
登録日2015-07-28
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr.,Sect.D, 71, 2015

 

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