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4M0R

Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).

Summary for 4M0R
Entry DOI10.2210/pdb4m0r/pdb
Related4GIU 4GKM 4IJ1
DescriptorAnthranilate phosphoribosyltransferase, 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, GLYCEROL, ... (6 entities in total)
Functional Keywordsmagnesium binding, phosphoribosylpyrophosphate, prpp, inhibitor complex, tri-anthranilate analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis
Total number of polymer chains2
Total formula weight78998.19
Authors
Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2013-08-02, release date: 2014-05-21, Last modification date: 2023-09-20)
Primary citationEvans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S.
Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15:852-864, 2014
Cited by
PubMed: 24623674
DOI: 10.1002/cbic.201300628
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.96 Å)
Structure validation

217705

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