4M0R
Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 644 A 600 |
| Chain | Residue |
| A | ASN138 |
| A | HOH877 |
| A | HOH886 |
| A | ALA179 |
| A | HIS183 |
| A | PRO184 |
| A | TYR186 |
| A | ARG187 |
| A | ALA190 |
| A | ARG193 |
| A | ARG194 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | PHE274 |
| A | ASP275 |
| A | PHE279 |
| A | TRP336 |
| A | HOH764 |
| A | HOH883 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 602 |
| Chain | Residue |
| A | ARG213 |
| A | LEU305 |
| A | GLY306 |
| A | GLY307 |
| A | ILE351 |
| A | ASP352 |
| A | GLY354 |
| A | HOH723 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 603 |
| Chain | Residue |
| A | ARG42 |
| A | ALA170 |
| A | GLU171 |
| A | VAL172 |
| A | GLY173 |
| A | HOH753 |
| A | HOH892 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 644 B 600 |
| Chain | Residue |
| B | THR108 |
| B | ASN138 |
| B | SER145 |
| B | ALA179 |
| B | HIS183 |
| B | TYR186 |
| B | ARG187 |
| B | ALA190 |
| B | ARG193 |
| B | ARG194 |
| B | GLY206 |
| B | HOH777 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD B 601 |
| Chain | Residue |
| B | ALA236 |
| B | LEU305 |
| B | ILE351 |
| B | ASP352 |
| B | GLU357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211 |
| Chain | Residue | Details |
| A | VAL106 | |
| B | VAL106 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY109 | |
| B | VAL116 | |
| B | LEU118 | |
| B | VAL134 | |
| B | GLY137 | |
| B | VAL192 | |
| B | LEU250 | |
| B | ASP251 | |
| A | VAL116 | |
| A | LEU118 | |
| A | VAL134 | |
| A | GLY137 | |
| A | VAL192 | |
| A | LEU250 | |
| A | ASP251 | |
| B | GLY109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5 |
| Chain | Residue | Details |
| A | ASN114 | |
| A | GLY146 | |
| B | ASN114 | |
| B | GLY146 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | VAL1 | |
| B | VAL1 |
