5BNE

Bianthranilate-like inhibitor with 6 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

Summary for 5BNE

• Entry DOI: 10.2210/pdb5bne/pdb
• Related: 3QR9 4IJ1
• Descriptor: Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-[(5-phosphonopentyl)oxy]benzoic acid, IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, lobenzarit-like analogue, trpd, anprt, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, magnesium binding, phosphoribosylpyrophosphate, prpp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 157338.45

Authors

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-05-26, release date: 2016-05-25, Last modification date: 2023-09-27)

• Primary citation: Evans, G.L.,Baker, E.N.,Lott, J.S.; Binding and mimicking of the phosphate-rich substrate, PRPP.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)