6HJX

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72

Summary for 6HJX

• Entry DOI: 10.2210/pdb6hjx/pdb
• Descriptor: Cys-loop ligand-gated ion channel, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ... (12 entities in total)
• Functional Keywords: ion channel, pentameric ligand-gated ion channel, cya-loop receptor, membrane protein
• Biological source: Dickeya chrysanthemi (Pectobacterium chrysanthemi); More
• Total number of polymer chains: 10
• Total formula weight: 249240.58

Authors

Spurny, R.,Govaerts, C.,Evans, G.L.,Pardon, E.,Steyaert, J.,Ulens, C. (deposition date: 2018-09-04, release date: 2019-10-09, Last modification date: 2024-01-17)

• Primary citation: Henault, C.M.,Govaerts, C.,Spurny, R.,Brams, M.,Estrada-Mondragon, A.,Lynch, J.,Bertrand, D.,Pardon, E.,Evans, G.L.,Woods, K.,Elberson, B.W.,Cuello, L.G.,Brannigan, G.,Nury, H.,Steyaert, J.,Baenziger, J.E.,Ulens, C.; A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.; Nat.Chem.Biol., 15:1156-1164, 2019; PubMed: 31591563; DOI: 10.1038/s41589-019-0369-4

Experimental method

X-RAY DIFFRACTION (2.5 Å)