6HJX
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue P6G A 501 |
| Chain | Residue |
| A | ALA9 |
| A | GLY45 |
| A | LYS46 |
| A | TRP72 |
| A | GLN139 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PTY A 502 |
| Chain | Residue |
| B | ILE281 |
| B | ALA288 |
| E | LYS49 |
| A | ALA217 |
| A | TRP224 |
| A | ARG301 |
| A | LEU302 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 503 |
| Chain | Residue |
| A | THR259 |
| A | GLN264 |
| A | HOH616 |
| E | SER202 |
| E | TRP206 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue LMT B 401 |
| Chain | Residue |
| A | TRP206 |
| B | THR259 |
| B | ILE267 |
| B | HOH543 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue P6G B 402 |
| Chain | Residue |
| B | THR44 |
| B | GLY45 |
| B | LYS46 |
| B | GLN138 |
| B | GLN139 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue LMT C 401 |
| Chain | Residue |
| B | TRP206 |
| C | THR259 |
| C | GLN264 |
| C | ALA268 |
| C | LEU315 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MES C 402 |
| Chain | Residue |
| C | ALA9 |
| C | ARG10 |
| C | TRP72 |
| C | TYR135 |
| C | GLN139 |
| C | GLN185 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue LMT D 401 |
| Chain | Residue |
| C | SER202 |
| C | TRP206 |
| D | THR259 |
| D | GLN264 |
| D | LEU315 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue P6G D 402 |
| Chain | Residue |
| D | ALA9 |
| D | ARG10 |
| D | TRP72 |
| D | GLN138 |
| D | GLN139 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue LMT E 401 |
| Chain | Residue |
| D | TRP206 |
| E | THR259 |
| E | GLN264 |
| E | PHE308 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue P6G E 402 |
| Chain | Residue |
| E | THR44 |
| E | GLY45 |
| E | TRP72 |
| E | GLN139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 300 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 45 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Motif: {"description":"Cys-loop"} |
| Chain | Residue | Details |
