4ZTV

Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP

Summary for 4ZTV

• Entry DOI: 10.2210/pdb4ztv/pdb
• Related: 3QR9 3QSA
• Descriptor: Anthranilate phosphoribosyltransferase, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione (3 entities in total)
• Functional Keywords: non-anthranilate-like inhibitor, trpd, anprt, transferase-transferase inhibitor complex, structural genomics, tb structural genomics consortium, tbsgc, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 78190.13

Authors

Evans, G.L.,Eom, J.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-05-15, release date: 2016-05-25, Last modification date: 2023-09-27)

• Primary citation: Evans, G.L.,Bulloch, E.M.M.,Eom, J.,Castell, A.,Short, F.L.,Baker, E.N.,Lott, J.S.; Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.01 Å)