1P4F
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![BU of 1p4f by Molmil](/molmil-images/mine/1p4f) | DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT | 分子名称: | 5,6-Dihydro-benzo[H]cinnolin-3-ylamine, Death-associated protein kinase 1 | 著者 | Velentza, A.V, Wainwright, M.S, Zasadzki, M, Mirzoeva, S, Haiech, J, Focia, P.J, Egli, M, Watterson, D.M. | 登録日 | 2003-04-23 | 公開日 | 2004-09-28 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorg.Med.Chem.Lett., 13, 2003
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8UJT
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![BU of 8ujt by Molmil](/molmil-images/mine/8ujt) | Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite urea lesion | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(XB9)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | 著者 | Tomar, R, Egli, M, Stone, M.P. | 登録日 | 2023-10-11 | 公開日 | 2024-03-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
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8EVE
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![BU of 8eve by Molmil](/molmil-images/mine/8eve) | HUMAN DNA POLYMERASE ETA INSERTION COMPLEX | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2022-10-20 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta. J.Biol.Chem., 299, 2023
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1NZG
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![BU of 1nzg by Molmil](/molmil-images/mine/1nzg) | Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine | 分子名称: | 5'-D(*GP*CP*GP*TP*AP*(3ME)P*AP*CP*GP*C)-3' | 著者 | Prhavc, M, Prakash, T.P, Minasov, G, Egli, M, Manoharan, M. | 登録日 | 2003-02-17 | 公開日 | 2003-08-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects Org.Lett., 5, 2003
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5L1L
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![BU of 5l1l by Molmil](/molmil-images/mine/5l1l) | |
5L1K
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![BU of 5l1k by Molmil](/molmil-images/mine/5l1k) | |
5L1J
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![BU of 5l1j by Molmil](/molmil-images/mine/5l1j) | |
3DVL
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![BU of 3dvl by Molmil](/molmil-images/mine/3dvl) | |
6CY0
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![BU of 6cy0 by Molmil](/molmil-images/mine/6cy0) | RNA octamer containing 2'-F, 4'-Cbeta-OMe U. | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2018-04-04 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46, 2018
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6CY4
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![BU of 6cy4 by Molmil](/molmil-images/mine/6cy4) | RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U. | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2018-04-04 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46, 2018
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6CY2
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![BU of 6cy2 by Molmil](/molmil-images/mine/6cy2) | RNA octamer containing 2'-OMe, 4'Calpha-OMe U. | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2018-04-04 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46, 2018
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6CXZ
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![BU of 6cxz by Molmil](/molmil-images/mine/6cxz) | RNA octamer containing 2'-F, 4'-Calpha-Me U. | 分子名称: | CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2018-04-04 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46, 2018
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8EVF
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![BU of 8evf by Molmil](/molmil-images/mine/8evf) | HUMAN DNA POLYMERASE ETA EXTENSION COMPLEX WITH AN INCOMING DCTP | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*G)-3'), ... | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2022-10-20 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta. J.Biol.Chem., 299, 2023
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4Y8W
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![BU of 4y8w by Molmil](/molmil-images/mine/4y8w) | Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex | 分子名称: | Cytochrome P450 21-hydroxylase, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Pallan, P.S, Lei, L, Egli, M. | 登録日 | 2015-02-16 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. J.Biol.Chem., 290, 2015
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6XHE
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![BU of 6xhe by Molmil](/molmil-images/mine/6xhe) | Structure of beta-prolinyl 5'-O-adenosine phosphoramidate | 分子名称: | 5'-O-[(S)-[(3S)-3-carboxypyrrolidin-1-yl](hydroxy)phosphoryl]adenosine, ADENOSINE MONOPHOSPHATE, Ribonuclease pancreatic | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2020-06-18 | 公開日 | 2021-03-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid. Angew.Chem.Int.Ed.Engl., 59, 2020
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6XHF
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![BU of 6xhf by Molmil](/molmil-images/mine/6xhf) | Structure of Phenylalanyl-5'-O-adenosine phosphoramidate | 分子名称: | (2~{S})-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]-3-phenyl-propanoic acid, CHLORIDE ION, Ribonuclease pancreatic | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2020-06-18 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid. Angew.Chem.Int.Ed.Engl., 59, 2020
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6XHD
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![BU of 6xhd by Molmil](/molmil-images/mine/6xhd) | Structure of Prolinyl-5'-O-adenosine phosphoramidate | 分子名称: | (2~{S})-1-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]pyrrolidine-2-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, ... | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2020-06-18 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid. Angew.Chem.Int.Ed.Engl., 59, 2020
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2QEG
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![BU of 2qeg by Molmil](/molmil-images/mine/2qeg) | B-DNA with 7-deaza-dG modification | 分子名称: | DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*DTP*DCP*(7GU)P*DCP*DG)-3') | 著者 | Wang, F, Li, F, Ganguly, M, Marky, L.A, Gold, B, Egli, M, Stone, M.P. | 登録日 | 2007-06-25 | 公開日 | 2008-05-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry, 47, 2008
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2QEF
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![BU of 2qef by Molmil](/molmil-images/mine/2qef) | X-ray structure of 7-deaza-dG and Z3dU modified duplex CGCGAATXCZCG | 分子名称: | DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*(ZDU)P*DCP*(7GU)P*DCP*DG)-3') | 著者 | Wang, F, Li, F, Ganguly, M, Marky, L.A, Gold, B, Egli, M, Stone, M.P. | 登録日 | 2007-06-25 | 公開日 | 2008-05-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry, 47, 2008
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6B82
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![BU of 6b82 by Molmil](/molmil-images/mine/6b82) | |
5JUM
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![BU of 5jum by Molmil](/molmil-images/mine/5jum) | Crystal Structure of Human DNA Polymerase Eta Inserting dCTP Opposite N-(2'-deoxyguanosin-8- yl)-3-aminobenzanthrone (C8-dG-ABA) | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | 著者 | Patra, A, Politica, D.A, Stone, M.P, Egli, M. | 登録日 | 2016-05-10 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase eta. Chembiochem, 17, 2016
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4YQW
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![BU of 4yqw by Molmil](/molmil-images/mine/4yqw) | Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | 著者 | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | 登録日 | 2015-03-13 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.064 Å) | 主引用文献 | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
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4YR3
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![BU of 4yr3 by Molmil](/molmil-images/mine/4yr3) | Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite Template G | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | 著者 | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | 登録日 | 2015-03-14 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
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5KT2
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![BU of 5kt2 by Molmil](/molmil-images/mine/5kt2) | Teranry complex of human DNA polymerase iota(26-445) inserting dCMPNPP opposite template G in the presence of Mg2+ | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | 著者 | Choi, J.Y, Patra, A, Yeom, M, Lee, Y.S, Zhang, Q, Egli, M, Guengerich, F.P. | 登録日 | 2016-07-11 | 公開日 | 2016-08-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.488 Å) | 主引用文献 | Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. J.Biol.Chem., 291, 2016
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4YP3
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![BU of 4yp3 by Molmil](/molmil-images/mine/4yp3) | Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | 著者 | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | 登録日 | 2015-03-12 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
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