8UJT

Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite urea lesion

Summary for 8UJT

• Entry DOI: 10.2210/pdb8ujt/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(XB9)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (6 entities in total)
• Functional Keywords: translation synthesis dna polymerase, urea-containing dna, non-hydrolysable nucleotide, dna binding protein, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 55154.46

Authors

Tomar, R.,Egli, M.,Stone, M.P. (deposition date: 2023-10-11, release date: 2024-03-20, Last modification date: 2024-04-03)

• Primary citation: Tomar, R.,Li, S.,Egli, M.,Stone, M.P.; Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.; Biochemistry, 63:754-766, 2024; PubMed: 38413007; DOI: 10.1021/acs.biochem.3c00569

Experimental method

X-RAY DIFFRACTION (2.31 Å)