6CXZ

RNA octamer containing 2'-F, 4'-Calpha-Me U.

Summary for 6CXZ

Related5VR4
DescriptorRNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III), ... (4 entities in total)
Functional Keywordsrna, oligonucleotide, modified base
Biological sourcesynthetic construct
Total number of polymer chains2
Total molecular weight5383.26
Authors
Harp, J.M.,Egli, M. (deposition date: 2018-04-04, release date: 2018-08-29, Last modification date: 2018-10-03)
Primary citation
Harp, J.M.,Guenther, D.C.,Bisbe, A.,Perkins, L.,Matsuda, S.,Bommineni, G.R.,Zlatev, I.,Foster, D.J.,Taneja, N.,Charisse, K.,Maier, M.A.,Rajeev, K.G.,Manoharan, M.,Egli, M.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46:8090-8104, 2018
PubMed: 30107495 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gky703
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeRSRZ outliers0.2130MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cxz
no rotation
Molmil generated image of 6cxz
rotated about x axis by 90°
Molmil generated image of 6cxz
rotated about y axis by 90°