6CY4

RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.

Summary for 6CY4

Related5VR4
DescriptorRNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3') (2 entities in total)
Functional Keywordsrna, oligonucleotide, modified base
Biological sourcesynthetic construct
Total number of polymer chains8
Total molecular weight21196.08
Authors
Harp, J.M.,Egli, M. (deposition date: 2018-04-04, release date: 2018-08-29, Last modification date: 2018-10-03)
Primary citation
Harp, J.M.,Guenther, D.C.,Bisbe, A.,Perkins, L.,Matsuda, S.,Bommineni, G.R.,Zlatev, I.,Foster, D.J.,Taneja, N.,Charisse, K.,Maier, M.A.,Rajeev, K.G.,Manoharan, M.,Egli, M.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46:8090-8104, 2018
PubMed: 30107495 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gky703
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.851 Å)
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Structure validation

RfreeRSRZ outliers0.2410MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cy4
no rotation
Molmil generated image of 6cy4
rotated about x axis by 90°
Molmil generated image of 6cy4
rotated about y axis by 90°