Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 172 results
2J6M
DownloadVisualize
BU of 2j6m by Molmil
Crystal structure of EGFR kinase domain in complex with AEE788
Descriptor: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
Authors:Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
Deposit date:2006-09-29
Release date:2007-04-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2J0L
DownloadVisualize
BU of 2j0l by Molmil
Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a phosphorylated activation loop.
Descriptor: FOCAL ADHESION KINASE 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Lietha, D, Cai, X, Li, Y, Schaller, M.D, Eck, M.J.
Deposit date:2006-08-03
Release date:2007-06-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Autoinhibition of Focal Adhesion Kinase
Cell(Cambridge,Mass.), 129, 2007
2J5F
DownloadVisualize
BU of 2j5f by Molmil
Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab
Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
Authors:Yun, C.-H, Eck, M.J.
Deposit date:2006-09-14
Release date:2007-02-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics.
Nat.Chem.Biol., 3, 2007
2J1D
DownloadVisualize
BU of 2j1d by Molmil
Crystallization of hDaam1 C-terminal Fragment
Descriptor: DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1, GLYCEROL, PHOSPHATE ION
Authors:Lu, J, Meng, W, Poy, F, Eck, M.J.
Deposit date:2006-08-10
Release date:2007-05-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Fh2 Domain of Daam1: Implications for Formin Regulation of Actin Assembly.
J.Mol.Biol., 369, 2007
2JKK
DownloadVisualize
BU of 2jkk by Molmil
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Descriptor: 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE, FOCAL ADHESION KINASE 1, SULFATE ION
Authors:Lietha, D, Eck, M.J.
Deposit date:2008-08-28
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation.
Plos One, 3, 2008
3ONX
DownloadVisualize
BU of 3onx by Molmil
Crystal structure of a domain of a protein involved in formation of actin cytoskeleton
Descriptor: Bud site selection protein 6
Authors:Tu, D, Eck, M.J.
Deposit date:2010-08-30
Release date:2011-10-12
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.904 Å)
Cite:Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.
Proc.Natl.Acad.Sci.USA, 109, 2012
7JXH
DownloadVisualize
BU of 7jxh by Molmil
HER2 in complex with JBJ-08-178-01
Descriptor: (2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide, Receptor tyrosine-protein kinase erbB-2
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.
Cancer Res., 82, 2022
7JXQ
DownloadVisualize
BU of 7jxq by Molmil
EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
Nat Cancer, 3, 2022
3OKQ
DownloadVisualize
BU of 3okq by Molmil
Crystal structure of a core domain of yeast actin nucleation cofactor Bud6
Descriptor: Bud site selection protein 6
Authors:Tu, D, Eck, M.J.
Deposit date:2010-08-25
Release date:2011-09-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.044 Å)
Cite:Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.
Proc.Natl.Acad.Sci.USA, 109, 2012
7JXW
DownloadVisualize
BU of 7jxw by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-28
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXI
DownloadVisualize
BU of 7jxi by Molmil
EGFR kinase (T790M/V948R) in complex with PF-06747775
Descriptor: Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXP
DownloadVisualize
BU of 7jxp by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXM
DownloadVisualize
BU of 7jxm by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.192 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7K1I
DownloadVisualize
BU of 7k1i by Molmil
EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-09-07
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7K1H
DownloadVisualize
BU of 7k1h by Molmil
EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-09-07
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXL
DownloadVisualize
BU of 7jxl by Molmil
EGFR kinase (T790M/V948R) in complex with AZ5104
Descriptor: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXK
DownloadVisualize
BU of 7jxk by Molmil
EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-08-27
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7KXZ
DownloadVisualize
BU of 7kxz by Molmil
Active conformation of EGFR kinase in complex with BI-4020
Descriptor: (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one, CHLORIDE ION, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-12-06
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of the macrocyclic inhibitor BI-4020 binding to the active and inactive conformations of EGFR kinase
To be published
7KY0
DownloadVisualize
BU of 7ky0 by Molmil
Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020
Descriptor: (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2020-12-06
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the macrocyclic inhibitor BI-4020 binding to the active and inactive conformations of EGFR kinase
To be published
7LG8
DownloadVisualize
BU of 7lg8 by Molmil
EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor
Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2021-01-19
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
Nat Commun, 13, 2022
3R7G
DownloadVisualize
BU of 3r7g by Molmil
Crystal structure of Spire KIND domain in complex with the tail of FMN2
Descriptor: Formin-2, Protein spire homolog 1
Authors:Kreutz, B, Vizcarra, C.L, Rodal, A.A, Toms, A.V, Lu, J, Quinlan, M.E, Eck, M.J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Proc.Natl.Acad.Sci.USA, 2011
3RBW
DownloadVisualize
BU of 3rbw by Molmil
Crystal structure of Spire KIND domain
Descriptor: Protein spire homolog 1
Authors:Vizcarra, C.L, Kreutz, B, Rodal, A.A, Toms, A.V, Lu, J, Zheng, W, Quinlan, M.E, Eck, M.J.
Deposit date:2011-03-30
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Proc.Natl.Acad.Sci.USA, 2011

219515

PDB entries from 2024-05-08

PDB statisticsPDBj update infoContact PDBjnumon