7K1H

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Summary for 7K1H

• Entry DOI: 10.2210/pdb7k1h/pdb
• Descriptor: Epidermal growth factor receptor, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide, ... (4 entities in total)
• Functional Keywords: egfr, kinase, allosteric, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 232768.78

Authors

Beyett, T.S.,Eck, M.J. (deposition date: 2020-09-07, release date: 2021-09-15, Last modification date: 2023-10-18)

• Primary citation: Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J.; Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors; Nat Commun, 13:2530-, 2022; DOI: 10.1038/s41467-022-30258-y

Experimental method

X-RAY DIFFRACTION (2.602 Å)