7K1H
EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (B, A, C, D, E...) | Epidermal growth factor receptor | polymer | 331 | 37738.5 | 6 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | G, I, K, M, O... (B, A, C, D, E...) | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 556.6 | 6 | Chemie (VNS) | |||
| 3 | H, J, L, N, P... (B, A, C, D, E...) | N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | non-polymer | 499.6 | 6 | Chemie (YY3) | |||
| 4 | S, T, U, V, W... (B, A, C, D, E...) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
B, A, C, D, E, F: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Arg 858 | Leu 858 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 226431.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 6337.5 | |
| All* | Total formula weight | 232768.8 |
