7K1H

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0004672	molecular_function	protein kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK

Chain	Residue	Details
B	LEU718-LYS745

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV

Chain	Residue	Details
B	LEU833-VAL845

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
B	ASP837
A	ASP837
C	ASP837
D	ASP837
E	ASP837
F	ASP837

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41

Chain	Residue	Details
B	LEU718
A	LEU718
C	LEU718
D	LEU718
E	LEU718
F	LEU718

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41

Chain	Residue	Details
B	LYS745
A	LYS745
C	LYS745
D	LYS745
E	LYS745
F	LYS745

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41

Chain	Residue	Details
B	THR790
A	THR790
C	THR790
D	THR790
E	THR790
F	THR790

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41

Chain	Residue	Details
B	ASP855
A	ASP855
C	ASP855
D	ASP855
E	ASP855
F	ASP855

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Important for interaction with PIK3C2B

Chain	Residue	Details
B	TYR1016
A	TYR1016
C	TYR1016
D	TYR1016
E	TYR1016
F	TYR1016

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:3138233, ECO:0007744|PubMed:18691976

Chain	Residue	Details
B	SER695
A	SER695
C	SER695
D	SER695
E	SER695
F	SER695

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674

Chain	Residue	Details
B	LYS745
A	LYS745
C	LYS745
D	LYS745
E	LYS745
F	LYS745

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:23774213

Chain	Residue	Details
B	TYR869
A	TYR869
C	TYR869
D	TYR869
E	TYR869
F	TYR869

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16083266, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER991
A	SER991
C	SER991
D	SER991
E	SER991
F	SER991

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
B	SER995
A	SER995
C	SER995
D	SER995
E	SER995
F	SER995

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0007744|PubMed:18669648

Chain	Residue	Details
B	TYR998
A	TYR998
C	TYR998
D	TYR998
E	TYR998
F	TYR998

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213

Chain	Residue	Details
B	TYR1016
A	TYR1016
C	TYR1016
D	TYR1016
E	TYR1016
F	TYR1016

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800

Chain	Residue	Details
B	LYS716
C	LYS737
C	LYS754
C	LYS867
D	LYS716
D	LYS737
D	LYS754
D	LYS867
E	LYS716
E	LYS737
E	LYS754
B	LYS737
E	LYS867
F	LYS716
F	LYS737
F	LYS754
F	LYS867
B	LYS754
B	LYS867
A	LYS716
A	LYS737
A	LYS754
A	LYS867
C	LYS716

---

site_id	SWS_FT_FI15
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144

Chain	Residue	Details
D	LYS929
D	LYS970
E	LYS929
E	LYS970
F	LYS929
F	LYS970
B	LYS929
B	LYS970
A	LYS929
A	LYS970
C	LYS929
C	LYS970

---

site_id	SWS_FT_FI16
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800

Chain	Residue	Details
B	LYS757
E	LYS960
F	LYS757
F	LYS960
B	LYS960
A	LYS757
A	LYS960
C	LYS757
C	LYS960
D	LYS757
D	LYS960
E	LYS757

---