7JXL
EGFR kinase (T790M/V948R) in complex with AZ5104
Summary for 7JXL
| Entry DOI | 10.2210/pdb7jxl/pdb |
| Descriptor | Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide (3 entities in total) |
| Functional Keywords | egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 152840.72 |
| Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2020-08-27, release date: 2021-09-08, Last modification date: 2024-10-30) |
| Primary citation | Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13:2530-, 2022 Cited by DOI: 10.1038/s41467-022-30258-yPDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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