7JXL
EGFR kinase (T790M/V948R) in complex with AZ5104
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, A, C, B) | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, F, G, H (D, A, C, B) | N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | non-polymer | 485.6 | 4 | Chemie (VO7) | |||
| 3 | I, J, K, L (D, A, C, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
D, A, C, B: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150898.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1942.3 | |
| All* | Total formula weight | 152840.7 |
