7K1I

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Summary for 7K1I

• Entry DOI: 10.2210/pdb7k1i/pdb
• Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38825.69

Authors

Beyett, T.S.,Eck, M.J. (deposition date: 2020-09-07, release date: 2021-09-15, Last modification date: 2023-10-18)

• Primary citation: Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J.; Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors; Nat Commun, 13:2530-, 2022; DOI: 10.1038/s41467-022-30258-y

Experimental method

X-RAY DIFFRACTION (3.202 Å)