7JXI
EGFR kinase (T790M/V948R) in complex with PF-06747775
Summary for 7JXI
Entry DOI | 10.2210/pdb7jxi/pdb |
Descriptor | Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide (2 entities in total) |
Functional Keywords | egfr, erbb1, kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 152568.16 |
Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2020-08-27, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13:2530-, 2022 Cited by DOI: 10.1038/s41467-022-30258-yPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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