8DQY
| |
4XI3
| Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene | 分子名称: | Bazedoxifene, Estrogen receptor | 著者 | Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L. | 登録日 | 2015-01-06 | 公開日 | 2016-01-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.491 Å) | 主引用文献 | The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife, 7, 2018
|
|
8DRG
| |
5IHJ
| |
4X9Q
| MnSOD-3 Room Temperature Structure | 分子名称: | MALONATE ION, MANGANESE (II) ION, SULFATE ION, ... | 著者 | Hunter, G.J, Trinh, C.H, Hunter, T, Bonetta, R, Stewart, E.E. | 登録日 | 2014-12-11 | 公開日 | 2015-11-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex. Protein Sci., 24, 2015
|
|
3GRT
| HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX | 分子名称: | 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE | 著者 | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | 登録日 | 1997-02-12 | 公開日 | 1997-08-12 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
|
|
7RX2
| |
7RXH
| |
6OCT
| Crystal structure of human KCTD16 T1 domain | 分子名称: | BTB/POZ domain-containing protein KCTD16 | 著者 | Zuo, H, Glaaser, I, Zhao, Y, Kurinov, I, Mosyak, L, Wang, H, Liu, J, Park, J, Frangaj, A, Sturchler, E, Zhou, M, McDonald, P, Geng, Y, Slesinger, P.A, Fan, Q.R. | 登録日 | 2019-03-25 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
7RX3
| |
7RXG
| |
7RWJ
| |
8E06
| |
5XOX
| Crystal structure of tRNA(His) guanylyltranserase from Saccharomyces cerevisiae | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Lee, K, Lee, E.H, Son, J, Hwang, K.Y. | 登録日 | 2017-05-31 | 公開日 | 2017-07-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of tRNA(His) guanylyltransferase from Saccharomyces cerevisiae Biochem. Biophys. Res. Commun., 490, 2017
|
|
4U7E
| The crystal structure of the complex of LIP5 NTD and IST1 MIM | 分子名称: | IST1 homolog, Vacuolar protein sorting-associated protein VTA1 homolog | 著者 | Guo, E.Z, Xu, Z. | 登録日 | 2014-07-30 | 公開日 | 2015-02-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains. J.Biol.Chem., 290, 2015
|
|
5LRV
| Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ... | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | 登録日 | 2016-08-22 | 公開日 | 2016-10-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature, 538, 2016
|
|
8OK6
| Variant Surface Glycoprotein VSG11 two monomers | 分子名称: | SULFATE ION, Variant surface glycoprotein, alpha-D-glucopyranose, ... | 著者 | Gkeka, A, Vlachou, E.P, Zeelen, J.P, Stebbins, C.E. | 登録日 | 2023-03-27 | 公開日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A structural classification of the variant surface glycoproteins of the African trypanosomey. Plos Negl Trop Dis, 17, 2023
|
|
8BIK
| Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455 | 分子名称: | (3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-[[6-chloranyl-5-[4-[4-[[dimethyl(oxidanyl)-$l^{4}-sulfanyl]amino]phenyl]phenyl]-3~{H}-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]furan-3-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... | 著者 | Schimpl, M, Mather, K.M, Boland, M.L, Rivers, E.L, Srivastava, A, Hemsley, P, Robinson, J, Wan, P.T, Hansen, J, Read, J.A, Trevaskis, J.L, Smith, D.M. | 登録日 | 2022-11-02 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Direct beta 1/ beta 2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis Biorxiv, 2024
|
|
8E05
| Structure of dimeric LRRK1 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | 著者 | Reimer, J.M, Lin, Y.X, Leschziner, A.E. | 登録日 | 2022-08-08 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat.Struct.Mol.Biol., 30, 2023
|
|
5IPZ
| Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide | 分子名称: | 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzene-1-sulfonamide, Carbonic anhydrase 4, ZINC ION | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2016-03-10 | 公開日 | 2017-03-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
|
|
8DSW
| |
8GAH
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
|
|
4U5L
| |
8GA3
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
|
|
4U5V
| IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | 分子名称: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | 登録日 | 2014-07-25 | 公開日 | 2015-05-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.968 Å) | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
|
|