5IPZ

Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide

Summary for 5IPZ

• Entry DOI: 10.2210/pdb5ipz/pdb
• Descriptor: Carbonic anhydrase 4, ZINC ION, 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzene-1-sulfonamide, ... (4 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 123113.59

Authors

Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2016-03-10, release date: 2017-03-29, Last modification date: 2024-01-10)

• Primary citation: Mickeviciute, A.,Timm, D.D.,Gedgaudas, M.,Linkuviene, V.,Chen, Z.,Waheed, A.,Michailoviene, V.,Zubriene, A.,Smirnov, A.,Capkauskaite, E.,Baranauskiene, L.,Jachno, J.,Revuckiene, J.,Manakova, E.,Grazulis, S.,Matuliene, J.,Di Cera, E.,Sly, W.S.,Matulis, D.; Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.; Eur. Biophys. J., 47:271-290, 2018; PubMed: 28975383; DOI: 10.1007/s00249-017-1256-0

Experimental method

X-RAY DIFFRACTION (2.1 Å)