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5IPZ

Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004089molecular_functioncarbonate dehydratase activity
A0005515molecular_functionprotein binding
A0005791cellular_componentrough endoplasmic reticulum
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0005886cellular_componentplasma membrane
A0006730biological_processone-carbon metabolic process
A0008270molecular_functionzinc ion binding
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016829molecular_functionlyase activity
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031526cellular_componentbrush border membrane
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0070062cellular_componentextracellular exosome
A0098552cellular_componentside of membrane
B0004089molecular_functioncarbonate dehydratase activity
B0005515molecular_functionprotein binding
B0005791cellular_componentrough endoplasmic reticulum
B0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0005886cellular_componentplasma membrane
B0006730biological_processone-carbon metabolic process
B0008270molecular_functionzinc ion binding
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016829molecular_functionlyase activity
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031526cellular_componentbrush border membrane
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0070062cellular_componentextracellular exosome
B0098552cellular_componentside of membrane
C0004089molecular_functioncarbonate dehydratase activity
C0005515molecular_functionprotein binding
C0005791cellular_componentrough endoplasmic reticulum
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005794cellular_componentGolgi apparatus
C0005802cellular_componenttrans-Golgi network
C0005886cellular_componentplasma membrane
C0006730biological_processone-carbon metabolic process
C0008270molecular_functionzinc ion binding
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0015701biological_processbicarbonate transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0016829molecular_functionlyase activity
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0031526cellular_componentbrush border membrane
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0070062cellular_componentextracellular exosome
C0098552cellular_componentside of membrane
D0004089molecular_functioncarbonate dehydratase activity
D0005515molecular_functionprotein binding
D0005791cellular_componentrough endoplasmic reticulum
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005886cellular_componentplasma membrane
D0006730biological_processone-carbon metabolic process
D0008270molecular_functionzinc ion binding
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0015701biological_processbicarbonate transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0016829molecular_functionlyase activity
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031526cellular_componentbrush border membrane
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0070062cellular_componentextracellular exosome
D0098552cellular_componentside of membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
AHIS98
AHIS100
AHIS123
A6CC302

site_idAC2
Number of Residues12
Detailsbinding site for residue 6CC A 302
ChainResidue
AVAL125
AVAL148
ALEU207
ATHR208
ATHR209
ATRP218
AZN301
AASN69
AGLN96
AHIS98
AHIS100
AHIS123

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN B 301
ChainResidue
BHIS98
BHIS100
BHIS123
B6CC302

site_idAC4
Number of Residues12
Detailsbinding site for residue 6CC B 302
ChainResidue
BASN69
BGLN96
BHIS98
BHIS100
BHIS123
BVAL125
BVAL148
BLEU207
BTHR208
BTHR209
BTRP218
BZN301

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN C 301
ChainResidue
CHIS98
CHIS100
CHIS123
C6CC302

site_idAC6
Number of Residues11
Detailsbinding site for residue 6CC C 302
ChainResidue
CASN69
CGLN96
CHIS98
CHIS100
CGLU110
CHIS123
CLEU205
CTHR206
CTHR207
CTRP216
CZN301

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN D 301
ChainResidue
DHIS98
DHIS100
DHIS123
DTHR206

Functional Information from PROSITE/UniProt
site_idPS00162
Number of Residues17
DetailsALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV
ChainResidueDetails
ASER109-VAL125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918
ChainResidueDetails
AHIS71
BHIS71
CHIS71
DHIS71

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:8942978
ChainResidueDetails
AHIS98
DHIS98
DHIS100
DHIS123
AHIS100
AHIS123
BHIS98
BHIS100
BHIS123
CHIS98
CHIS100
CHIS123

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00918
ChainResidueDetails
ATHR208
BTHR208
CTHR206
DTHR206

site_idSWS_FT_FI4
Number of Residues4
DetailsLIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:7625839
ChainResidueDetails
ASER267
BSER267
CSER265
DSER265

221716

PDB entries from 2024-06-26

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