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PDB: 119 件
3G40
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Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter
分子名称: Na-K-Cl cotransporter
著者Warmuth, S, Zimmermann, I, Dutzler, R.
登録日2009-02-03
公開日2009-04-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray Structure of the C-Terminal Domain of a Prokaryotic Cation-Chloride Cotransporter
Structure, 17, 2009
2EXW
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BU of 2exw by Molmil
Crystal structure of a EcClC-Fab complex in the absence of bound ions
分子名称: Fab Fragment (Heavy Chain), Fab Fragment (Light Chain), H(+)/Cl(-) exchange transporter clcA
著者Lobet, S, Dutzler, R.
登録日2005-11-09
公開日2006-01-24
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Ion-binding properties of the ClC chloride selectivity filter.
Embo J., 25, 2006
2EXY
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Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions
分子名称: Fab Fragment (Heavy Chain), Fab Fragment (Light Chain), H(+)/Cl(-) exchange transporter clcA
著者Lobet, S, Dutzler, R.
登録日2005-11-09
公開日2006-01-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Ion-binding properties of the ClC chloride selectivity filter.
Embo J., 25, 2006
2EZ0
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BU of 2ez0 by Molmil
Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment
分子名称: BROMIDE ION, Fab Fragment (Heavy Chain), Fab Fragment (Light Chain), ...
著者Lobet, S, Dutzler, R.
登録日2005-11-10
公開日2006-01-24
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.54 Å)
主引用文献Ion-binding properties of the ClC chloride selectivity filter.
Embo J., 25, 2006
8B42
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BU of 8b42 by Molmil
Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel.
分子名称: Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
著者Sawicka, M, Dutzler, R.
登録日2022-09-19
公開日2022-12-14
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B8G
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Cryo-EM structure of Ca2+-free mTMEM16F F518H mutant in Digitonin
分子名称: Anoctamin-6
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-04
公開日2022-11-16
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8B8K
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Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed
分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-04
公開日2022-11-16
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8B8J
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Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin
分子名称: Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-04
公開日2022-11-16
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8BC0
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Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed
分子名称: Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-14
公開日2022-11-16
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8B8M
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Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed
分子名称: Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-04
公開日2022-11-16
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8BC1
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Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN
分子名称: Anoctamin-6,mTMEM16F, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-14
公開日2022-11-16
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8B40
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Structure of homomeric LRRC8C Volume-Regulated Anion Channel
分子名称: Volume-regulated anion channel subunit LRRC8C
著者Sawicka, M, Dutzler, R.
登録日2022-09-19
公開日2022-12-14
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8BEN
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LRR domain Structure of the LRRC8C protein
分子名称: Volume-regulated anion channel subunit LRRC8C
著者Sawicka, M, Dutzler, R.
登録日2022-10-21
公開日2022-12-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B41
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Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1
分子名称: Synthetic nanobody Sb1, Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
著者Sawicka, M, Dutzler, R.
登録日2022-09-19
公開日2022-12-14
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B8Q
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Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+
分子名称: Anoctamin-6, CALCIUM ION
著者Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R.
登録日2022-10-04
公開日2022-12-21
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
8C03
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Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation
分子名称: 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, Solute carrier family 40 member 1
著者Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C.
登録日2022-12-15
公開日2023-03-22
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
8BZY
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Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation
分子名称: 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ...
著者Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C.
登録日2022-12-15
公開日2023-03-22
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
8C02
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BU of 8c02 by Molmil
Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation
分子名称: Solute carrier family 40 member 1, Sybody3
著者Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C.
登録日2022-12-15
公開日2023-03-22
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (4.09 Å)
主引用文献Structures of ferroportin in complex with its specific inhibitor vamifeport.
Elife, 12, 2023
7QIA
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Structure of apo-EleNRMT in complex with two nanobodies at 3.5A
分子名称: Divalent metal cation transporter, Nanobody 1, Nanobody 2
著者Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
登録日2021-12-14
公開日2021-12-29
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QIC
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Structure of magnesium-bound EleNRMT in complex with two nanobodies at 4.1A
分子名称: Divalent metal cation transporter, MAGNESIUM ION, Nanobody 1, ...
著者Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
登録日2021-12-14
公開日2021-12-29
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QJI
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X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A
分子名称: Divalent metal cation transporter, Elen-Nanobody-complex
著者Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
登録日2021-12-16
公開日2022-02-02
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QJJ
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X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A
分子名称: Divalent metal cation transporter, Elen-Nb1-Nb2, MANGANESE (II) ION
著者Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
登録日2021-12-16
公開日2022-02-02
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (4.6 Å)
主引用文献Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
2PFI
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Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka
分子名称: CHLORIDE ION, Chloride channel protein ClC-Ka, IODIDE ION
著者Markovic, S, Dutzler, R.
登録日2007-04-05
公開日2007-06-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Structure of the Cytoplasmic Domain of the Chloride Channel ClC-Ka Reveals a Conserved Interaction Interface.
Structure, 15, 2007
8RTS
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Structure of a homomeric human LRRC8C Volume-Regulated Anion Channel
分子名称: Volume-regulated anion channel subunit LRRC8C
著者Rutz, S, Quinodoz, M, Peter, V, Garavelli, L, Innes, M, Kellenberger, S, Barone, A, Campos-Xavier, B, Unger, S, Rivolta, C, Dutzler, R, Superti-Furga, A.
登録日2024-01-29
公開日2024-11-13
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献Genetic activation of a Volume-Regulated Anion Channel yields a multisystem disorder
To Be Published
8QZC
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Structure of calcium-bound mTMEM16A(ac)-L647V/I733V chloride channel at 3.29 A resolution
分子名称: Anoctamin-1, CALCIUM ION
著者Lam, A.K.M, Dutzler, R.
登録日2023-10-26
公開日2023-12-06
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Mechanistic basis of ligand efficacy in the calcium-activated chloride channel TMEM16A.
Embo J., 42, 2023

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