8JPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jpb by Molmil](/molmil-images/mine/8jpb) | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
|
|
8JPE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jpe by Molmil](/molmil-images/mine/8jpe) | Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
|
|
8JPD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jpd by Molmil](/molmil-images/mine/8jpd) | Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | Beta-adrenergic receptor kinase 1, STAUROSPORINE | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
|
|
8I2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i2h by Molmil](/molmil-images/mine/8i2h) | Follicle stimulating hormone receptor | 分子名称: | Follicle-stimulating hormone receptor | 著者 | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | 登録日 | 2023-01-14 | 公開日 | 2023-03-22 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
|
|
8I2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i2g by Molmil](/molmil-images/mine/8i2g) | FSHR-Follicle stimulating hormone-compound 716340-Gs complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | 登録日 | 2023-01-14 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
|
|
8PVM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pvm by Molmil](/molmil-images/mine/8pvm) | formaldehyde-inhibited [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant C299D | 分子名称: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FORMYL GROUP, ... | 著者 | Duan, J, Hofmann, E, Happe, T. | 登録日 | 2023-07-18 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Insights into the Molecular Mechanism of Formaldehyde Inhibition of [FeFe]-Hydrogenases. J.Am.Chem.Soc., 145, 2023
|
|
8QM3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qm3 by Molmil](/molmil-images/mine/8qm3) | |
7XW7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xw7 by Molmil](/molmil-images/mine/7xw7) | TSHR-K1-70 complex | 分子名称: | K1-70 scFv, Thyrotropin receptor | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-05-26 | 公開日 | 2022-08-17 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
|
|
7XW5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xw5 by Molmil](/molmil-images/mine/7xw5) | TSHR-thyroid stimulating hormone-Gs-ML109 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-05-26 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
|
|
7XW6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xw6 by Molmil](/molmil-images/mine/7xw6) | TSHR-Gs-M22 antibody-ML109 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-05-26 | 公開日 | 2022-08-17 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
|
|
7WQ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wq4 by Molmil](/molmil-images/mine/7wq4) | Galanin-bound galanin receptor 2 in complex with Gq | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
|
|
7WQ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wq3 by Molmil](/molmil-images/mine/7wq3) | Galanin-bound galanin receptor 1 in complex with Gi | 分子名称: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
|
|
7FIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fij by Molmil](/molmil-images/mine/7fij) | luteinizing hormone/choriogonadotropin receptor | 分子名称: | Lutropin-choriogonadotropic hormone receptor | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | 登録日 | 2021-07-31 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes. Nature, 598, 2021
|
|
7FIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fih by Molmil](/molmil-images/mine/7fih) | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex | 分子名称: | 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide, Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, ... | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | 登録日 | 2021-07-31 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes. Nature, 598, 2021
|
|
7FII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fii by Molmil](/molmil-images/mine/7fii) | luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex | 分子名称: | Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, Glycoprotein hormones alpha chain, ... | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | 登録日 | 2021-07-31 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes. Nature, 598, 2021
|
|
7FIG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fig by Molmil](/molmil-images/mine/7fig) | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid antibody VHH fragment Nb35, Choriogonadotropin subunit beta 3, ... | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | 登録日 | 2021-07-31 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes. Nature, 598, 2021
|
|
9IJA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9ija by Molmil](/molmil-images/mine/9ija) | A local Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Taste receptor type 2 member 14 | 著者 | Yuan, Q, Duan, J, Tao, L, Xu, E.H. | 登録日 | 2024-06-21 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist. Cell Res., 2024
|
|
9IIW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9iiw by Molmil](/molmil-images/mine/9iiw) | |
9IIX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9iix by Molmil](/molmil-images/mine/9iix) | A Cryo-EM structure of Bitter taste receptor TAS2R14 with Ggust | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Duan, J, Tao, L, Xu, E.H. | 登録日 | 2024-06-21 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist. Cell Res., 2024
|
|
9IJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9ij9 by Molmil](/molmil-images/mine/9ij9) | A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yuan, Q, Duan, J, Tao, L, Xu, E.H. | 登録日 | 2024-06-21 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist. Cell Res., 2024
|
|
8J6I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j6i by Molmil](/molmil-images/mine/8j6i) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
|
|
8J6L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j6l by Molmil](/molmil-images/mine/8j6l) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
|
|
8J6J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j6j by Molmil](/molmil-images/mine/8j6j) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
|
|
7QHF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qhf by Molmil](/molmil-images/mine/7qhf) | [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI), variant G302S | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | 著者 | Brocks, C, Duan, J, Hofmann, E, Happe, T. | 登録日 | 2021-12-12 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | A Dynamic Water Channel Affects O 2 Stability in [FeFe]-Hydrogenases. Chemsuschem, 2023
|
|
8CJY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cjy by Molmil](/molmil-images/mine/8cjy) | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant S357T | 分子名称: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | 著者 | Brocks, C, Duan, J, Hofmann, E, Happe, T. | 登録日 | 2023-02-13 | 公開日 | 2023-10-25 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Dynamic Water Channel Affects O 2 Stability in [FeFe]-Hydrogenases. Chemsuschem, 17, 2024
|
|