6NY1
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![BU of 6ny1 by Molmil](/molmil-images/mine/6ny1) | CasX-gRNA-DNA(30bp) State II | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | Deposit date: | 2019-02-10 | Release date: | 2019-02-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566, 2019
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8FYB
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![BU of 8fyb by Molmil](/molmil-images/mine/8fyb) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYC
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![BU of 8fyc by Molmil](/molmil-images/mine/8fyc) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | Descriptor: | Cas1, Cas2-DEDDh, DEDDh, ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYD
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![BU of 8fyd by Molmil](/molmil-images/mine/8fyd) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | Descriptor: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8VXY
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![BU of 8vxy by Molmil](/molmil-images/mine/8vxy) | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | Authors: | Tuck, O.T, Hu, J.J, Doudna, J.A. | Deposit date: | 2024-02-06 | Release date: | 2024-03-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Hachiman is a genome integrity sensor. Biorxiv, 2024
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8VXA
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![BU of 8vxa by Molmil](/molmil-images/mine/8vxa) | |
8VX9
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![BU of 8vx9 by Molmil](/molmil-images/mine/8vx9) | |
8VXC
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![BU of 8vxc by Molmil](/molmil-images/mine/8vxc) | |
7Z20
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![BU of 7z20 by Molmil](/molmil-images/mine/7z20) | 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Mitropoulou, A, Plessa, E, Wlodarski, T, Ahn, M, Sidhu, H, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J. | Deposit date: | 2022-02-25 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | Modulating co-translational protein folding by rational design and ribosome engineering. Nat Commun, 13, 2022
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8FYA
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![BU of 8fya by Molmil](/molmil-images/mine/8fya) | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FY9
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![BU of 8fy9 by Molmil](/molmil-images/mine/8fy9) | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER) | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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7THB
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![BU of 7thb by Molmil](/molmil-images/mine/7thb) | Crystal structure of an RNA-5'/DNA-3' strand exchange junction | Descriptor: | DNA (5'-D(*GP*AP*TP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*TP*AP*AP*GP*CP*AP*GP*CP*AP*TP*C)-3'), RNA (5'-R(*AP*GP*CP*UP*UP*AP*C)-3') | Authors: | Cofsky, J.C, Knott, G.J, Gee, C.L, Doudna, J.A. | Deposit date: | 2022-01-10 | Release date: | 2022-04-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Crystal structure of an RNA/DNA strand exchange junction. Plos One, 17, 2022
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8DC2
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![BU of 8dc2 by Molmil](/molmil-images/mine/8dc2) | Cryo-EM structure of CasLambda (Cas12l) bound to crRNA and DNA | Descriptor: | CasLambda, DNA NTS, DNA TS, ... | Authors: | Al-Shayeb, B, Skopintsev, P, Soczek, K, Doudna, J. | Deposit date: | 2022-06-15 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors. Cell, 185, 2022
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6VPC
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![BU of 6vpc by Molmil](/molmil-images/mine/6vpc) | Structure of the SpCas9 DNA adenine base editor - ABE8e | Descriptor: | CRISPR-associated endonuclease Cas9, Cas9 (SpCas9) single-guide RNA (sgRNA), DNA non-target strand (NTS), ... | Authors: | Knott, G.J, Lapinaite, A, Doudna, J.A. | Deposit date: | 2020-02-03 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | DNA capture by a CRISPR-Cas9-guided adenine base editor. Science, 369, 2020
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4TXZ
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![BU of 4txz by Molmil](/molmil-images/mine/4txz) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP | Descriptor: | Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TY0
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![BU of 4ty0 by Molmil](/molmil-images/mine/4ty0) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG | Descriptor: | ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ... | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4UIJ
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![BU of 4uij by Molmil](/molmil-images/mine/4uij) | Crystal structure of the BTB domain of KCTD13 | Descriptor: | BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 1, CHLORIDE ION | Authors: | Pinkas, D.M, Sanvitale, C.E, Sorell, F.J, Solcan, N, Goubin, S, Canning, P, Williams, E, Chaikuad, A, Dixon Clarke, S.E, Tallant, C, Fonseca, M, Chalk, R, Doutch, J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2015-03-30 | Release date: | 2015-11-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. Biochem. J., 474, 2017
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5K4C
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![BU of 5k4c by Molmil](/molmil-images/mine/5k4c) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2 | Descriptor: | Eukaryotic translation initiation factor 3 subunit D, GLYCEROL | Authors: | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | Deposit date: | 2016-05-20 | Release date: | 2016-07-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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5K4B
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![BU of 5k4b by Molmil](/molmil-images/mine/5k4b) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1 | Descriptor: | CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit D | Authors: | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | Deposit date: | 2016-05-20 | Release date: | 2016-07-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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5K4D
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![BU of 5k4d by Molmil](/molmil-images/mine/5k4d) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 3 | Descriptor: | Eukaryotic translation initiation factor 3 subunit D | Authors: | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | Deposit date: | 2016-05-20 | Release date: | 2016-07-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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6MCB
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![BU of 6mcb by Molmil](/molmil-images/mine/6mcb) | |
7S38
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![BU of 7s38 by Molmil](/molmil-images/mine/7s38) | Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-04 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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7S37
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![BU of 7s37 by Molmil](/molmil-images/mine/7s37) | Cas9:sgRNA (S. pyogenes) in the open-protein conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-04 | Release date: | 2022-04-20 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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7S3H
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![BU of 7s3h by Molmil](/molmil-images/mine/7s3h) | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-06 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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7S36
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![BU of 7s36 by Molmil](/molmil-images/mine/7s36) | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-04 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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