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PDB: 50 件
7KZ7
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BU of 7kz7 by Molmil
Crystals Structure of the Mutated Protease Domain of Botulinum Neurotoxin X (X4130B1).
分子名称: 1,2-ETHANEDIOL, Botulinum neurotoxin type X, GLYCEROL, ...
著者Blum, T.R, Liu, H, Packer, M.S, Xiong, X, Lee, P.G, Zhang, S, Richter, M, Minasov, G, Satchell, K.J.F, Dong, M, Liu, D.R, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-12-10
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.
Science, 371, 2021
6G5G
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BU of 6g5g by Molmil
Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
著者Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P.
登録日2018-03-29
公開日2019-01-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
6G5F
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BU of 6g5f by Molmil
Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1
分子名称: Botulinum neurotoxin type B, GLYCEROL, MALONATE ION, ...
著者Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P.
登録日2018-03-29
公開日2019-01-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
6G5K
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BU of 6g5k by Molmil
Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1
分子名称: Botulinum neurotoxin type B, Synaptotagmin-1
著者Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P.
登録日2018-03-29
公開日2019-01-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
6LU8
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BU of 6lu8 by Molmil
Cryo-EM structure of a human pre-60S ribosomal subunit - state A
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N.
登録日2020-01-26
公開日2020-08-26
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
Nat Commun, 11, 2020
6LQM
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BU of 6lqm by Molmil
Cryo-EM structure of a pre-60S ribosomal subunit - state C
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N.
登録日2020-01-14
公開日2020-08-26
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
Nat Commun, 11, 2020
6LSR
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BU of 6lsr by Molmil
Cryo-EM structure of a pre-60S ribosomal subunit - state B
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N.
登録日2020-01-20
公開日2020-08-26
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
Nat Commun, 11, 2020
6LSS
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BU of 6lss by Molmil
Cryo-EM structure of a pre-60S ribosomal subunit - state preA
分子名称: 28S rRNA, 5S rRNA, 60S ribosomal protein L11, ...
著者Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N.
登録日2020-01-20
公開日2020-08-26
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
Nat Commun, 11, 2020
5H64
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BU of 5h64 by Molmil
Cryo-EM structure of mTORC1
分子名称: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
著者Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H.
登録日2016-11-10
公開日2017-01-25
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
5G06
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BU of 5g06 by Molmil
Cryo-EM structure of yeast cytoplasmic exosome
分子名称: EXOSOME COMPLEX COMPONENT CSL4, EXOSOME COMPLEX COMPONENT MTR3, EXOSOME COMPLEX COMPONENT RRP4, ...
著者Liu, J.J, Niu, C.Y, Wu, Y, Tan, D, Wang, Y, Ye, M.D, Liu, Y, Zhao, W.W, Zhou, K, Liu, Q.S, Dai, J.B, Yang, X.R, Dong, M.Q, Huang, N, Wang, H.W.
登録日2016-03-17
公開日2016-06-15
最終更新日2017-08-02
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
3JCT
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BU of 3jct by Molmil
Cryo-em structure of eukaryotic pre-60S ribosomal subunits
分子名称: 60S ribosomal protein L11-A, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ...
著者Wu, S, Kumcuoglu, B, Yan, K.G, Brown, H, Zhang, Y.X, Tan, D, Gamalinda, M, Yuan, Y, Li, Z.F, Jakovljevic, J, Ma, C.Y, Lei, J.L, Dong, M.Q, Woolford Jr, J.L, Gao, N.
登録日2016-03-09
公開日2016-06-01
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
Nature, 534, 2016
4ISR
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BU of 4isr by Molmil
Binding domain of Botulinum neurotoxin DC in complex with rat synaptotagmin II
分子名称: Neurotoxin, SULFATE ION, Synaptotagmin-2
著者Berntsson, R.P.-A, Peng, L, Svensson, L.M, Dong, M, Stenmark, P.
登録日2013-01-17
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II.
Structure, 21, 2013
4ISQ
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BU of 4isq by Molmil
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
分子名称: GLYCEROL, Neurotoxin, SULFATE ION, ...
著者Berntsson, R.P.-A, Peng, L, Svensson, L.M, Dong, M, Stenmark, P.
登録日2013-01-17
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II.
Structure, 21, 2013
5JMC
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BU of 5jmc by Molmil
Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C
分子名称: Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C
著者Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R.
登録日2016-04-28
公開日2016-06-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
4KBB
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BU of 4kbb by Molmil
Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a
分子名称: Botulinum neurotoxin type B, CHLORIDE ION, MAGNESIUM ION, ...
著者Berntsson, R.P.A, Peng, L, Dong, M, Stenmark, P.
登録日2013-04-23
公開日2013-07-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of dual receptor binding to botulinum neurotoxin B.
Nat Commun, 4, 2013
6F4E
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BU of 6f4e by Molmil
Crystal structure of the zinc-free catalytic domain of botulinum neurotoxin X
分子名称: Catalytic domain of botulinum neurotoxin X, DI(HYDROXYETHYL)ETHER
著者Masuyer, G, Henriksson, L, Kosenina, S, Zhang, S, Barkho, S, Shen, Y, Dong, M, Stenmark, P.
登録日2017-11-29
公開日2018-03-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
6F47
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BU of 6f47 by Molmil
Crystal structure of the catalytic domain of botulinum neurotoxin X
分子名称: Catalytic domain of botulinum neurotoxin X, ZINC ION
著者Masuyer, G, Henriksson, L, Kosenina, S, Zhang, S, Barkho, S, Shen, Y, Dong, M, Stenmark, P.
登録日2017-11-29
公開日2018-03-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
4QD2
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BU of 4qd2 by Molmil
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
分子名称: CALCIUM ION, Cadherin-1, Hemagglutinin component HA17, ...
著者Lee, K, Zhong, X, Gu, S, Kruel, A, Dorner, M.B, Perry, K, Rummel, A, Dong, M, Jin, R.
登録日2014-05-13
公開日2014-06-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
Science, 344, 2014
6BXL
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BU of 6bxl by Molmil
Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM
分子名称: 2-(3-amino-3-carboxypropyl)histidine synthase, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE
著者Torelli, A.T, Fenwick, M.K, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXM
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BU of 6bxm by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAM/cleaved SAM
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALPHA-AMINOBUTYRIC ACID, Diphthamide biosynthesis enzyme Dph2, ...
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXN
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BU of 6bxn by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAM
分子名称: Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.079 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXK
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BU of 6bxk by Molmil
Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and MTA
分子名称: 2-(3-amino-3-carboxypropyl)histidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, IRON/SULFUR CLUSTER, ...
著者Torelli, A.T, Fenwick, M.K, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.347 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXO
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BU of 6bxo by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAH
分子名称: Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.655 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
5Z10
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BU of 5z10 by Molmil
Structure of the mechanosensitive Piezo1 channel
分子名称: Piezo-type mechanosensitive ion channel component 1
著者Zhao, Q, Zhou, H, Chi, S, Wang, Y, Wang, J, Geng, J, Wu, K, Liu, W, Zhang, T, Dong, M.-Q, Wang, J, Li, X, Xiao, B.
登録日2017-12-22
公開日2018-01-31
最終更新日2020-01-29
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献Structure and mechanogating mechanism of the Piezo1 channel.
Nature, 554, 2018
5YFP
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BU of 5yfp by Molmil
Cryo-EM Structure of the Exocyst Complex
分子名称: Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ...
著者Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W.
登録日2017-09-21
公開日2018-01-31
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM structure of the exocyst complex
Nat. Struct. Mol. Biol., 25, 2018
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