6BXK
Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and MTA
Summary for 6BXK
Entry DOI | 10.2210/pdb6bxk/pdb |
Descriptor | 2-(3-amino-3-carboxypropyl)histidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | diphthamide biosynthesis, radical sam enzyme, biosynthetic protein |
Biological source | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
Total number of polymer chains | 2 |
Total formula weight | 86566.65 |
Authors | Torelli, A.T.,Fenwick, M.K.,Zhang, Y.,Dong, M.,Kathiresan, V.,Carantoa, J.D.,Dzikovski, B.,Lancaster, K.M.,Freed, J.H.,Hoffman, B.M.,Lin, H.,Ealick, S.E. (deposition date: 2017-12-18, release date: 2018-04-11, Last modification date: 2023-10-04) |
Primary citation | Dong, M.,Kathiresan, V.,Fenwick, M.K.,Torelli, A.T.,Zhang, Y.,Caranto, J.D.,Dzikovski, B.,Sharma, A.,Lancaster, K.M.,Freed, J.H.,Ealick, S.E.,Hoffman, B.M.,Lin, H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359:1247-1250, 2018 Cited by PubMed: 29590073DOI: 10.1126/science.aao6595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.347 Å) |
Structure validation
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