6BXL

Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM

Summary for 6BXL

Entry DOI	10.2210/pdb6bxl/pdb
Descriptor	2-(3-amino-3-carboxypropyl)histidine synthase, S-ADENOSYLMETHIONINE, IRON/SULFUR CLUSTER, ... (4 entities in total)
Functional Keywords	diphthamide biosynthesis, radical sam enzyme, biosynthetic protein
Biological source	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Total number of polymer chains	2
Total formula weight	86576.73
Authors	Torelli, A.T.,Fenwick, M.K.,Zhang, Y.,Dong, M.,Kathiresan, V.,Carantoa, J.D.,Dzikovski, B.,Lancaster, K.M.,Freed, J.H.,Hoffman, B.M.,Lin, H.,Ealick, S.E. (deposition date: 2017-12-18, release date: 2018-04-11, Last modification date: 2023-10-04)
Primary citation	Dong, M.,Kathiresan, V.,Fenwick, M.K.,Torelli, A.T.,Zhang, Y.,Caranto, J.D.,Dzikovski, B.,Sharma, A.,Lancaster, K.M.,Freed, J.H.,Ealick, S.E.,Hoffman, B.M.,Lin, H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359:1247-1250, 2018 Cited by PubMed: 29590073 DOI: 10.1126/science.aao6595 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.301 Å)

Structure validation