5GRF
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5C3R
| Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and 5-hydroxymethyluracil (5hmU) | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 5-HYDROXYMETHYL URACIL, ... | Authors: | Li, W, Zhang, T, Ding, J. | Deposit date: | 2015-06-17 | Release date: | 2015-10-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res., 43, 2015
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5GRE
| Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), citrate and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, ... | Authors: | Ma, T, Peng, Y, Ding, J. | Deposit date: | 2016-08-11 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 7, 2017
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8JDB
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyoctanoic acid | Descriptor: | (2R)-2-oxidanyloctanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDD
| Crystal structure of H405A mLDHD in apo form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDT
| Crystal structure of mLDHD in complex with 2-ketobutanoic acid | Descriptor: | 2-KETOBUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDG
| Crystal structure of H405A mLDHD in complex with D-2-hydroxybutanoic acid | Descriptor: | (2R)-2-oxidanylbutanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDU
| Crystal structure of mLDHD in complex with 2-ketovaleric acid | Descriptor: | 2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDQ
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid | Descriptor: | (2R)-2-hydroxy-4-methylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDN
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyvaleric acid | Descriptor: | (2R)-2-oxidanylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDX
| Crystal structure of mLDHD in complex with 2-ketoisovaleric acid | Descriptor: | 3-METHYL-2-OXOBUTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDF
| Crystal structure of H405A mLDHD in complex with D-lactate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDC
| Crystal structure of mLDHD in apo form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDO
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyhexanoic acid | Descriptor: | (2R)-2-hydroxyhexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDZ
| Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | Descriptor: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDS
| Crystal structure of mLDHD in complex with Pyruvate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, PYRUVIC ACID, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.636 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDE
| Crystal structure of mLDHD in complex with D-lactate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.729 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDV
| Crystal structure of mLDHD in complex with 2-ketohexanoic acid | Descriptor: | 2-Ketohexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDY
| Crystal structure of mLDHD in complex with 2-ketoisocaproic acid | Descriptor: | 2-OXO-4-METHYLPENTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDP
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | Descriptor: | DEAMINOHYDROXYVALINE, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDR
| Crystal structure of H405A mLDHD in complex with D-2-hydroxy-3-methyl-valeric acid | Descriptor: | (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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5GRI
| Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and citrate | Descriptor: | CITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, ... | Authors: | Ma, T, Peng, Y, Ding, J. | Deposit date: | 2016-08-11 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 7, 2017
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8JYY
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5GRL
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5C3S
| Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and 5-formyluracil (5fU) | Descriptor: | 1,2-ETHANEDIOL, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, 2-OXOGLUTARIC ACID, ... | Authors: | Li, W, Zhang, T, Ding, J. | Deposit date: | 2015-06-17 | Release date: | 2015-10-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res., 43, 2015
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