4ZS7
 
 | | Structural mimicry of receptor interaction by antagonistic IL-6 antibodies | | Descriptor: | Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain | | Authors: | Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H. | | Deposit date: | 2015-05-13 | | Release date: | 2016-05-04 | | Last modified: | 2016-07-06 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
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2XA3
 | | crystal structure of the broadly neutralizing llama VHH D7 and its mode of HIV-1 gp120 interaction | | Descriptor: | LLAMA HEAVY CHAIN ANTIBODY D7, SULFATE ION | | Authors: | Hinz, A, Lutje Hulsik, D, Forsman, A, Koh, W, Belrhali, H, Gorlani, A, de Haard, H, Weiss, R.A, Verrips, T, Weissenhorn, W. | | Deposit date: | 2010-03-29 | | Release date: | 2010-05-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of the neutralizing Llama V(HH) D7 and its mode of HIV-1 gp120 interaction.
PLoS ONE, 5, 2010
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4R90
 | | Anti CD70 Llama glama Fab 27B3 | | Descriptor: | Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ... | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.746 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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4R96
 | | Structure of a Llama Glama Fab 48A2 against human cMet | | Descriptor: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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4GRW
 | | Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) | | Descriptor: | Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Nanobody 124C4, ... | | Authors: | Desmyter, A, Spinelli, S, Button, C, Saunders, M, de Haard, H, Rommelaere, H, Union, A, Cambillau, C. | | Deposit date: | 2012-08-27 | | Release date: | 2014-02-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.
Front Immunol, 8, 2017
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1SJX
 | | Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, immunoglobulin VH domain | | Authors: | Dolk, E, van der Vaart, M, Hulsik, D.L, Vriend, G, de Haard, H, Spinelli, S, Cambillau, C, Frenken, L, Verrips, T. | | Deposit date: | 2004-03-04 | | Release date: | 2005-03-15 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.
Appl.Environ.Microbiol., 71, 2005
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7PHS
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5M2J
 | | Complex between human TNF alpha and Llama VHH2 | | Descriptor: | Anti-(ED-B) scFV, Tumor necrosis factor | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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5M2M
 | | Complex between human TNF alpha and Llama VHH3 | | Descriptor: | Llama nanobody VHH3, Tumor necrosis factor | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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5M2I
 | | Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | | Descriptor: | Tumor necrosis factor, VHH1 | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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1ZRU
 | | structure of the lactophage p2 receptor binding protein in complex with glycerol | | Descriptor: | GLYCEROL, lactophage p2 receptor binding protein | | Authors: | Spinelli, S, Tremblay, D.M, Tegoni, M, Blangy, S, Huyghe, C, Desmyter, A, Labrie, S, de Haard, H, Moineau, S, Cambillau, C, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2005-05-22 | | Release date: | 2006-03-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Receptor-binding protein of Lactococcus lactis phages: identification and characterization of the saccharide receptor-binding site.
J.Bacteriol., 188, 2006
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6GFF
 | | Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ... | | Authors: | Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S. | | Deposit date: | 2018-04-30 | | Release date: | 2018-11-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 362, 2018
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