4GRW

Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)

Summary for 4GRW

• Entry DOI: 10.2210/pdb4grw/pdb
• Descriptor: Interleukin-23 subunit alpha, Interleukin-12 subunit beta, Nanobody 124C4, ... (7 entities in total)
• Functional Keywords: cytokine, immunoglobulin fold, vhh domain, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 199002.13

Authors

Desmyter, A.,Spinelli, S.,Button, C.,Saunders, M.,de Haard, H.,Rommelaere, H.,Union, A.,Cambillau, C. (deposition date: 2012-08-27, release date: 2014-02-19, Last modification date: 2023-12-27)

• Primary citation: Desmyter, A.,Spinelli, S.,Boutton, C.,Saunders, M.,Blachetot, C.,de Haard, H.,Denecker, G.,Van Roy, M.,Cambillau, C.,Rommelaere, H.; Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.; Front Immunol, 8:884-884, 2017; PubMed: 28871249; DOI: 10.3389/fimmu.2017.00884

Experimental method

X-RAY DIFFRACTION (2.55 Å)