4GRW
Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Interleukin-23 subunit alpha | polymer | 189 | 20749.7 | 2 | UniProt (Q9NPF7) Pfam (PF16649) | Homo sapiens (human) | IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19 |
| 2 | B, D (B, D) | Interleukin-12 subunit beta | polymer | 328 | 37212.9 | 2 | UniProt (P29460) Pfam (PF10420) | Homo sapiens (human) | IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2 |
| 3 | E, G (E, G) | Nanobody 124C4 | polymer | 125 | 13402.8 | 2 | Lama glama | ||
| 4 | F, J (F, J) | Nanobody 37D5 | polymer | 126 | 13847.1 | 2 | Lama glama | ||
| 5 | H, I (H, I) | Nanobody 22E11 | polymer | 123 | 13377.7 | 2 | Lama glama | ||
| 6 | K, L (K, L) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 7 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 710 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 197180.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| All* | Total formula weight | 199002.1 |
