6MNC
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![BU of 6mnc by Molmil](/molmil-images/mine/6mnc) | CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE | Descriptor: | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, DI(HYDROXYETHYL)ETHER, Estradiol 17-beta-dehydrogenase 1 | Authors: | Li, T, Stephen, P, Zhu, D.W, Lin, S.X. | Deposit date: | 2018-10-01 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition. Febs J., 286, 2019
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6N9J
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2GC0
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2GO3
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![BU of 2go3 by Molmil](/molmil-images/mine/2go3) | Crystal structure of Aquifex aeolicus LpxC complexed with imidazole. | Descriptor: | CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... | Authors: | Gennadios, H.A, Whittington, D.A, Li, X, Fierke, C.A, Christianson, D.W. | Deposit date: | 2006-04-12 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase Biochemistry, 45, 2006
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6MUW
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![BU of 6muw by Molmil](/molmil-images/mine/6muw) | The structure of the Plasmodium falciparum 20S proteasome. | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6N8O
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![BU of 6n8o by Molmil](/molmil-images/mine/6n8o) | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6N8J
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![BU of 6n8j by Molmil](/molmil-images/mine/6n8j) | Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal protein L11-A, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6MUV
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![BU of 6muv by Molmil](/molmil-images/mine/6muv) | The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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2FOQ
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2FOU
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![BU of 2fou by Molmil](/molmil-images/mine/2fou) | Human Carbonic Anhydrase II complexed with two-prong inhibitors | Descriptor: | COPPER (II) ION, Carbonic Anhydrase II, GLYCEROL, ... | Authors: | Jude, K.M, Christianson, D.W. | Deposit date: | 2006-01-14 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2FOV
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![BU of 2fov by Molmil](/molmil-images/mine/2fov) | Human Carbonic Anhydrase II complexed with two-prong inhibitors | Descriptor: | ACETONITRILE, COPPER (II) ION, Carbonic Anhydrase II, ... | Authors: | Jude, K.M, Christianson, D.W. | Deposit date: | 2006-01-14 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2FOY
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![BU of 2foy by Molmil](/molmil-images/mine/2foy) | Human Carbonic Anhydrase I complexed with a two-prong inhibitor | Descriptor: | Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER | Authors: | Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W. | Deposit date: | 2006-01-14 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2FUH
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![BU of 2fuh by Molmil](/molmil-images/mine/2fuh) | Solution Structure of the UbcH5c/Ub Non-covalent Complex | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 D3 | Authors: | Brzovic, P.S, Lissounov, A, Hoyt, D.W, Klevit, R.E. | Deposit date: | 2006-01-26 | Release date: | 2006-03-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination. Mol.Cell, 21, 2006
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2FYO
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![BU of 2fyo by Molmil](/molmil-images/mine/2fyo) | Crystal structure of rat carnitine palmitoyltransferase 2 in space group P43212 | Descriptor: | Carnitine O-palmitoyltransferase II, mitochondrial | Authors: | Rufer, A.C, Thoma, R, Benz, J, Stihle, M, Gsell, B, De Roo, E, Banner, D.W, Mueller, F, Chomienne, O, Hennig, M. | Deposit date: | 2006-02-08 | Release date: | 2007-02-08 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment Structure, 14, 2006
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2FOS
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![BU of 2fos by Molmil](/molmil-images/mine/2fos) | Human Carbonic Anhydrase II complexed with two-prong inhibitors | Descriptor: | COPPER (II) ION, Carbonic Anhydrase II, ZINC ION, ... | Authors: | Jude, K.M, Christianson, D.W. | Deposit date: | 2006-01-13 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2H4N
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![BU of 2h4n by Molmil](/molmil-images/mine/2h4n) | H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE | Descriptor: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION | Authors: | Lesburg, C.A, Christianson, D.W. | Deposit date: | 1997-05-29 | Release date: | 1997-09-17 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
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2HG2
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2FW3
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![BU of 2fw3 by Molmil](/molmil-images/mine/2fw3) | Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326 | Descriptor: | (3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE, Carnitine O-palmitoyltransferase II, mitochondrial | Authors: | Rufer, A.C, Thoma, R, Benz, J, Stihle, M, Gsell, B, De Roo, E, Banner, D.W, Mueller, F, Chomienne, O, Hennig, M. | Deposit date: | 2006-02-01 | Release date: | 2007-02-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment Structure, 14, 2006
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6N8N
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![BU of 6n8n by Molmil](/molmil-images/mine/6n8n) | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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2GO4
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![BU of 2go4 by Molmil](/molmil-images/mine/2go4) | Crystal structure of Aquifex aeolicus LpxC complexed with TU-514 | Descriptor: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, CHLORIDE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | Authors: | Gennadios, H.A, Whittington, D.A, Li, X, Fierke, C.A, Christianson, D.W. | Deposit date: | 2006-04-12 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase Biochemistry, 45, 2006
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6O4P
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![BU of 6o4p by Molmil](/molmil-images/mine/6o4p) | The crystal structure of the interleukin 11 alpha receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11 receptor subunit alpha, ... | Authors: | Aizel, K, Metcalfe, R.D, Griffin, M.D.W. | Deposit date: | 2019-02-28 | Release date: | 2020-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.429 Å) | Cite: | The structure of the extracellular domains of human interleukin 11 alpha receptor reveals mechanisms of cytokine engagement. J.Biol.Chem., 295, 2020
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6N8L
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![BU of 6n8l by Molmil](/molmil-images/mine/6n8l) | Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6MUX
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![BU of 6mux by Molmil](/molmil-images/mine/6mux) | The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6N8M
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![BU of 6n8m by Molmil](/molmil-images/mine/6n8m) | Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit | Descriptor: | 5.8S RNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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2GC1
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![BU of 2gc1 by Molmil](/molmil-images/mine/2gc1) | |