6O4P

The crystal structure of the interleukin 11 alpha receptor

Summary for 6O4P

• Entry DOI: 10.2210/pdb6o4p/pdb
• Descriptor: Interleukin-11 receptor subunit alpha, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cytokine, interleukin, receptor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 78874.29

Authors

Aizel, K.,Metcalfe, R.D.,Griffin, M.D.W. (deposition date: 2019-02-28, release date: 2020-05-06, Last modification date: 2020-07-29)

• Primary citation: Metcalfe, R.D.,Aizel, K.,Zlatic, C.O.,Nguyen, P.M.,Morton, C.J.,Lio, D.S.,Cheng, H.C.,Dobson, R.C.J.,Parker, M.W.,Gooley, P.R.,Putoczki, T.L.,Griffin, M.D.W.; The structure of the extracellular domains of human interleukin 11 alpha receptor reveals mechanisms of cytokine engagement.; J.Biol.Chem., 295:8285-8301, 2020; PubMed: 32332100; DOI: 10.1074/jbc.RA119.012351

Experimental method

X-RAY DIFFRACTION (3.429 Å)