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6MNC

CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE

Summary for 6MNC
Entry DOI10.2210/pdb6mnc/pdb
DescriptorEstradiol 17-beta-dehydrogenase 1, DI(HYDROXYETHYL)ETHER, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (4 entities in total)
Functional Keywords17beta-hsd1, estrone, functional analyses, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight70354.49
Authors
Li, T.,Stephen, P.,Zhu, D.W.,Lin, S.X. (deposition date: 2018-10-01, release date: 2019-04-03, Last modification date: 2023-10-11)
Primary citationLi, T.,Stephen, P.,Zhu, D.W.,Shi, R.,Lin, S.X.
Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.
Febs J., 286:2155-2166, 2019
Cited by
PubMed: 30768851
DOI: 10.1111/febs.14784
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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