6MNC
CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE
Summary for 6MNC
Entry DOI | 10.2210/pdb6mnc/pdb |
Descriptor | Estradiol 17-beta-dehydrogenase 1, DI(HYDROXYETHYL)ETHER, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (4 entities in total) |
Functional Keywords | 17beta-hsd1, estrone, functional analyses, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70354.49 |
Authors | Li, T.,Stephen, P.,Zhu, D.W.,Lin, S.X. (deposition date: 2018-10-01, release date: 2019-04-03, Last modification date: 2023-10-11) |
Primary citation | Li, T.,Stephen, P.,Zhu, D.W.,Shi, R.,Lin, S.X. Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition. Febs J., 286:2155-2166, 2019 Cited by PubMed: 30768851DOI: 10.1111/febs.14784 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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