2FW3

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326

Summary for 2FW3

DescriptorCarnitine O-palmitoyltransferase II, mitochondrial, (3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE (3 entities in total)
Functional Keywordscentral six-stranded beta-sheet, transferase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationMitochondrion inner membrane ; Peripheral membrane protein ; Matrix side  P18886
Total number of polymer chains1
Total molecular weight73965.71
Authors
Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (deposition date: 2006-02-01, release date: 2007-02-01, Last modification date: 2017-10-18)
Primary citation
Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M.
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment
Structure, 14:713-723, 2006
PubMed: 16615901 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2006.01.008
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.295101.1%5.9%0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2fw3
no rotation
Molmil generated image of 2fw3
rotated about x axis by 90°
Molmil generated image of 2fw3
rotated about y axis by 90°
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