2A07
| Crystal Structure of Foxp2 bound Specifically to DNA. | Descriptor: | 5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3', 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3', Forkhead box protein P2, ... | Authors: | Stroud, J.C, Wu, Y, Bates, D.L, Han, A, Nowick, K, Paabo, S, Tong, H, Chen, L. | Deposit date: | 2005-06-16 | Release date: | 2006-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Forkhead Domain of FOXP2 Bound to DNA. Structure, 14, 2006
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5IJD
| The crystal structure of mouse TLR4/MD-2/lipid A complex | Descriptor: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B. | Deposit date: | 2016-03-01 | Release date: | 2016-04-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc.Natl.Acad.Sci.USA, 113, 2016
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2AD9
| Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA | Descriptor: | 5'-R(*CP*UP*CP*UP*CP*U)-3', Polypyrimidine tract-binding protein 1 | Authors: | Oberstrass, F.C, Auweter, S.D, Erat, M, Hargous, Y, Henning, A, Wenter, P, Reymond, L, Pitsch, S, Black, D.L, Allain, F.H.T. | Deposit date: | 2005-07-20 | Release date: | 2005-10-04 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of PTB bound to RNA: specific binding and implications for splicing regulation Science, 309, 2005
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5WUC
| Structural basis for conductance through TRIC cation channels | Descriptor: | SODIUM ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-07-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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5IWO
| Bacterial sodium channel pore domain, low bromide | Descriptor: | BROMIDE ION, Ion transport protein | Authors: | Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L. | Deposit date: | 2016-03-22 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell, 164, 2016
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2A2I
| Aquifex aeolicus KDO8PS in complex with PEP, A5P, Zn2+ | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, ARABINOSE-5-PHOSPHATE, PHOSPHOENOLPYRUVATE, ... | Authors: | Kona, F, Xu, X, Lu, J, Martin, P, Gatti, D.L. | Deposit date: | 2005-06-22 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis. Biochemistry, 48, 2009
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2AS5
| Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA. | Descriptor: | 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', 5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', Forkhead box protein P2, ... | Authors: | Wu, Y, Stroud, J.C, Borde, M, Bates, D.L, Guo, L, Han, A, Rao, A, Chen, L. | Deposit date: | 2005-08-22 | Release date: | 2006-08-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT. Cell(Cambridge,Mass.), 126, 2006
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2B1G
| Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase | Descriptor: | 7-(3,4-DIHYDROXY-5R-HYDROXYMETHYLTETRAHYDROFURAN-2-YL)-2,2-DIOXO-1,2R,3R,7-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-4S-ONE, Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, ... | Authors: | Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A. | Deposit date: | 2005-09-15 | Release date: | 2006-11-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. J.Biol.Chem., 282, 2007
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2EF9
| Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, ARABINOSE-5-PHOSPHATE, PHOSPHOENOLPYRUVATE | Authors: | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | Deposit date: | 2007-02-22 | Release date: | 2007-04-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases Biochemistry, 46, 2007
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1MCD
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | Descriptor: | Immunoglobulin lambda-1 light chain, PEPTIDE N-ACETYL-D-PHE-B-ALA-L-HIS-D-PRO-NH2 | Authors: | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | Deposit date: | 1993-02-25 | Release date: | 1994-01-31 | Last modified: | 2020-03-04 | Method: | X-RAY DIFFRACTION | Cite: | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
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1MNC
| STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET | Descriptor: | CALCIUM ION, METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID, NEUTROPHIL COLLAGENASE, ... | Authors: | Stams, T, Spurlino, J.C, Smith, D.L, Rubin, B. | Deposit date: | 1994-01-12 | Release date: | 1995-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human neutrophil collagenase reveals large S1' specificity pocket. Nat.Struct.Biol., 1, 1994
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1M6P
| EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR | Descriptor: | 6-O-phosphono-alpha-D-mannopyranose, CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, MANGANESE (II) ION | Authors: | Roberts, D.L, Weix, D.J, Dahms, N.M, Kim, J.J.-P. | Deposit date: | 1998-04-19 | Release date: | 1999-04-27 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. Cell(Cambridge,Mass.), 93, 1998
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1MCJ
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | Descriptor: | ACETYL GROUP, AMINO GROUP, D-PHENYLALANINE, ... | Authors: | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | Deposit date: | 1993-02-25 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
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3BX8
| Engineered Human Lipocalin 2 (LCN2), apo-form | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ENGINEERED HUMAN LIPOCALIN 2, PENTAETHYLENE GLYCOL | Authors: | Schonfeld, D.L, Chatwell, L, Skerra, A. | Deposit date: | 2008-01-11 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin To be Published
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1MUK
| reovirus lambda3 native structure | Descriptor: | MINOR CORE PROTEIN LAMBDA 3 | Authors: | Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. | Deposit date: | 2002-09-24 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | RNA Synthesis in a Cage-Structural Studies of Reovirus Polymerase lambda3 Cell(Cambridge,Mass.), 111, 2002
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1MWH
| REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MANGANESE (II) ION, MINOR CORE PROTEIN LAMBDA 3 | Authors: | Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. | Deposit date: | 2002-09-29 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | RNA Synthesis in a Cage-Structural Studies of Reovirus Polymerase lambda3 Cell(Cambridge,Mass.), 111, 2002
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1N38
| reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 3'-DEOXY-URIDINE 5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*C)-3', ... | Authors: | Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. | Deposit date: | 2002-10-25 | Release date: | 2002-12-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3 Cell(Cambridge,Mass.), 111, 2002
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1LRQ
| Aquifex aeolicus KDO8P synthase H185G mutant in complex with PEP, A5P and Cadmium | Descriptor: | ARABINOSE-5-PHOSPHATE, CADMIUM ION, KDO-8-phosphate synthetase, ... | Authors: | Wang, J, Duewel, H.S, Stuckey, J.A, Woodard, R.W, Gatti, D.L. | Deposit date: | 2002-05-15 | Release date: | 2002-11-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Function of His185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase J.Mol.Biol., 324, 2002
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1MCR
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | Descriptor: | IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN), PEPTIDE N-ACETYL-L-HIS-D-PRO-OH | Authors: | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | Deposit date: | 1993-02-25 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
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1NJS
| human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid | Descriptor: | N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase | Authors: | Zhang, Y, Desharnais, J, Marsilje, T.H, Li, C, Hedrick, M.P, Gooljarsingh, L.T, Tavassoli, A, Benkovic, S.J, Olson, A.J, Boger, D.L, Wilson, I.A. | Deposit date: | 2003-01-02 | Release date: | 2003-06-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid Biochemistry, 42, 2003
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3D03
| 1.9A structure of Glycerophoshphodiesterase (GpdQ) from Enterobacter aerogenes | Descriptor: | COBALT (II) ION, Phosphohydrolase | Authors: | Hadler, K.S, Tanifum, E, Yip, S.H.-C, Miti, N, Guddat, L.W, Jackson, C.J, Gahan, L.R, Carr, P.D, Nguyen, K, Ollis, D.L, Hengge, A.C, Larrabee, J.A, Schenk, G. | Deposit date: | 2008-04-30 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J.Am.Chem.Soc., 130, 2008
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1NPR
| CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS NUSG IN C222(1) | Descriptor: | Transcription antitermination protein nusG | Authors: | Knowlton, J.R, Bubunenko, M, Andrykovitch, M, Guo, W, Routzhan, K.M, Waugh, D.S, Court, D.L, Ji, X. | Deposit date: | 2003-01-18 | Release date: | 2003-03-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | A Spring-Loaded State of NusG in Its Functional Cycle Is Suggested by X-ray Crystallography and Supported by
Site-Directed Mutants Biochemistry, 42, 2003
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1LRO
| Aquifex aeolicus KDO8P synthase H185G mutant in complex with PEP and Cadmium | Descriptor: | CADMIUM ION, KDO-8-phosphate synthetase, PHOSPHATE ION, ... | Authors: | Wang, J, Duewel, H.S, Stuckey, J.A, Woodard, R.W, Gatti, D.L. | Deposit date: | 2002-05-15 | Release date: | 2002-11-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Function of His185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase J.Mol.Biol., 324, 2002
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1LEV
| PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR | Descriptor: | 3-(2-CARBOXY-ETHYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID, 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, ... | Authors: | Wright, S.W, Carlo, A.A, Danley, D.E, Hageman, D.L, Karam, G.A, Mansour, M.N, McClure, L.D, Pandit, J, Schulte, G.K, Treadway, J.L, Wang, I.-K, Bauer, P.H. | Deposit date: | 2002-04-10 | Release date: | 2002-10-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg.Med.Chem.Lett., 13, 2003
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1OD0
| Family 1 b-glucosidase from Thermotoga maritima | Descriptor: | BETA-GLUCOSIDASE A | Authors: | Gloster, T, Zechel, D.L, Boraston, A.B, Boraston, C.M, Macdonald, J.M, Tilbrook, D.M, Stick, R.V, Davies, G.J. | Deposit date: | 2003-02-12 | Release date: | 2003-03-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to Beta-Glucosidases J.Am.Chem.Soc., 125, 2003
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