2AS5

Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.

Summary for 2AS5

Related1a02 1owr 2a07
Descriptor5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', Nuclear factor of activated T-cells, cytoplasmic 2, ... (6 entities in total)
Functional Keywordsforkhead domain, rhr domain, rel homology region, ig fold, winged helix-turn-helix, b-dna, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm Q13469
Nucleus (Probable) O15409
Total number of polymer chains8
Total molecular weight113024.94
Authors
Wu, Y.,Stroud, J.C.,Borde, M.,Bates, D.L.,Guo, L.,Han, A.,Rao, A.,Chen, L. (deposition date: 2005-08-22, release date: 2006-08-08, Last modification date: 2011-07-13)
Primary citation
Wu, Y.,Borde, M.,Heissmeyer, V.,Feuerer, M.,Lapan, A.D.,Stroud, J.C.,Bates, D.L.,Guo, L.,Han, A.,Ziegler, S.F.,Mathis, D.,Benoist, C.,Chen, L.,Rao, A.
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.
Cell(Cambridge,Mass.), 126:375-387, 2006
PubMed: 16873067 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2006.05.042
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.291284.6%3.8%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2as5
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Molmil generated image of 2as5
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Molmil generated image of 2as5
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More Biological unit images

Molmil generated image of 2as5
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Molmil generated image of 2as5
rotated about x axis by 90°
Molmil generated image of 2as5
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2as5.pdb2.gz [81.94 KB])
Coordinate files for Biological unit (2as5.pdb1.gz [81.87 KB])