2AS5
Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3' | polymer | 21 | 6491.2 | 2 | |||
| 2 | B, D (B, D) | 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3' | polymer | 21 | 6389.2 | 2 | |||
| 3 | E, F (N, M) | Nuclear factor of activated T-cells, cytoplasmic 2 | polymer | 287 | 32582.1 | 2 | UniProt (Q13469) Pfam (PF00554) Pfam (PF16179) | Homo sapiens (human) | T cell transcription factor NFAT1, NFAT pre-existing subunit, NF-ATp |
| 4 | G, H (F, G) | Forkhead box protein P2 | polymer | 93 | 11025.6 | 2 | UniProt (O15409) Pfam (PF00250) | Homo sapiens (human) | CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein |
| 5 | I, J (F, G) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, L, M, N, O... (A, B, C, D, N...) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
F, G: 502 - 594 (UniProt: O15409)
| PDB | External Database | Details |
|---|---|---|
| Ile 502 | Asp 502 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 112976.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 48.6 | |
| All* | Total formula weight | 113024.9 |
