2W5I
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![BU of 2w5i by Molmil](/molmil-images/mine/2w5i) | RNASE A-AP3A COMPLEX | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, RIBONUCLEASE PANCREATIC | Authors: | Chavali, G.B, Holloway, D.E, Baker, M.D, Acharya, K.R. | Deposit date: | 2008-12-10 | Release date: | 2009-02-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Influence of Naturally-Occurring 5'-Pyrophosphate-Linked Substituents on the Binding of Adenylic Inhibitors to Ribonuclease A: An X-Ray Crystallographic Study. Biopolymers, 91, 2009
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2R4B
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![BU of 2r4b by Molmil](/molmil-images/mine/2r4b) | ErbB4 kinase domain complexed with a thienopyrimidine inhibitor | Descriptor: | N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine, Receptor tyrosine-protein kinase erbB-4 | Authors: | Shewchuk, L.M, Uehling, D.E. | Deposit date: | 2007-08-31 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2XAG
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![BU of 2xag by Molmil](/molmil-images/mine/2xag) | Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine | Descriptor: | 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | Authors: | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | Deposit date: | 2010-03-31 | Release date: | 2010-05-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2QS3
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![BU of 2qs3 by Molmil](/molmil-images/mine/2qs3) | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution | Descriptor: | 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-5-phenylthiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... | Authors: | Alushin, G.M, Jane, D.E, Mayer, M.L. | Deposit date: | 2007-07-30 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology, 56, 2009
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2Q9Y
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![BU of 2q9y by Molmil](/molmil-images/mine/2q9y) | Trichodiene synthase: Complex with Mg, inorganic pyrophosphate, and benzyl triethyl ammonium cation | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, ... | Authors: | Vedula, L.S, Zhao, Y, Coates, R.M, Koyama, T, Cane, D.E, Christianson, D.W. | Deposit date: | 2007-06-14 | Release date: | 2008-04-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Exploring biosynthetic diversity with trichodiene synthase. Arch.Biochem.Biophys., 466, 2007
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2XAF
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![BU of 2xaf by Molmil](/molmil-images/mine/2xaf) | Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine | Descriptor: | 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | Authors: | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | Deposit date: | 2010-03-31 | Release date: | 2010-05-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2XAQ
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![BU of 2xaq by Molmil](/molmil-images/mine/2xaq) | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) | Descriptor: | 3-{4-[(PHENYLCARBONYL)AMINO]PHENYL}PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | Authors: | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | Deposit date: | 2010-03-31 | Release date: | 2010-05-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2XAS
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![BU of 2xas by Molmil](/molmil-images/mine/2xas) | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) | Descriptor: | 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | Authors: | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | Deposit date: | 2010-03-31 | Release date: | 2010-05-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2XAH
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![BU of 2xah by Molmil](/molmil-images/mine/2xah) | Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine | Descriptor: | 3-PHENYLPROPANAL, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | Authors: | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | Deposit date: | 2010-03-31 | Release date: | 2010-05-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2LIG
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![BU of 2lig by Molmil](/molmil-images/mine/2lig) | THREE-DIMENSIONAL STRUCTURES OF THE LIGAND-BINDING DOMAIN OF THE BACTERIAL ASPARTATE RECEPTOR WITH AND WITHOUT A LIGAND | Descriptor: | 1,10-PHENANTHROLINE, ASPARTATE RECEPTOR, ASPARTIC ACID, ... | Authors: | Kim, S.-H, Yeh, J.I, Prive, G.G, Milburn, M, Scott, W, Koshland Junior, D.E. | Deposit date: | 1995-04-18 | Release date: | 1995-09-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand. Science, 254, 1991
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2LAI
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![BU of 2lai by Molmil](/molmil-images/mine/2lai) | |
2L9I
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![BU of 2l9i by Molmil](/molmil-images/mine/2l9i) | |
2LL6
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![BU of 2ll6 by Molmil](/molmil-images/mine/2ll6) | Solution NMR structure of CaM bound to iNOS CaM binding domain peptide | Descriptor: | Calmodulin, Nitric oxide synthase, inducible | Authors: | Piazza, M, Futrega, K, Spratt, D.E, Dieckmann, T, Guillemette, J.G. | Deposit date: | 2011-10-29 | Release date: | 2012-05-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and Dynamics of Calmodulin (CaM) Bound to Nitric Oxide Synthase Peptides: Effects of a Phosphomimetic CaM Mutation. Biochemistry, 51, 2012
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2LGV
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![BU of 2lgv by Molmil](/molmil-images/mine/2lgv) | Rbx1 | Descriptor: | E3 ubiquitin-protein ligase RBX1, ZINC ION | Authors: | Spratt, D.E, Shaw, G.S. | Deposit date: | 2011-08-02 | Release date: | 2012-03-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Selective recruitment of an e2~ubiquitin complex by an e3 ubiquitin ligase. J.Biol.Chem., 287, 2012
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2M48
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![BU of 2m48 by Molmil](/molmil-images/mine/2m48) | Solution Structure of IBR-RING2 Tandem Domain from Parkin | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE PARKIN, ZINC ION | Authors: | Noh, Y.J, Mercier, P, Spratt, D.E, Shaw, G.S. | Deposit date: | 2013-01-30 | Release date: | 2013-05-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nat Commun, 4, 2013
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2LWR
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![BU of 2lwr by Molmil](/molmil-images/mine/2lwr) | Solution Structure of RING2 Domain from Parkin | Descriptor: | SD01679p, ZINC ION | Authors: | Mercier, P, Spratt, D.E, Manczyk, N, Shaw, G.S. | Deposit date: | 2012-08-06 | Release date: | 2013-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nat Commun, 4, 2013
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2M9Y
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![BU of 2m9y by Molmil](/molmil-images/mine/2m9y) | |
2NC6
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![BU of 2nc6 by Molmil](/molmil-images/mine/2nc6) | Solution Structure of N-L-idosylated Pin1 WW Domain | Descriptor: | Pin1 WW Domain, beta-L-idopyranose | Authors: | Hsu, C, Park, S, Mortenson, D.E, Foley, B, Wang, X, Woods, R.J, Case, D.A, Powers, E.T, Wong, C, Dyson, H, Kelly, J.W. | Deposit date: | 2016-03-20 | Release date: | 2016-06-08 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate. J.Am.Chem.Soc., 138, 2016
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2MXD
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![BU of 2mxd by Molmil](/molmil-images/mine/2mxd) | Solution structure of VPg of porcine sapovirus | Descriptor: | Viral protein genome-linked | Authors: | Kim, J, Hwang, H, Min, H, Yun, H, Cho, K, Pelton, J.G, Wemmer, D.E, Lee, C. | Deposit date: | 2014-12-24 | Release date: | 2015-04-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the porcine sapovirus VPg core reveals a stable three-helical bundle with a conserved surface patch. Biochem.Biophys.Res.Commun., 459, 2015
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2NPB
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![BU of 2npb by Molmil](/molmil-images/mine/2npb) | NMR solution structure of mouse SelW | Descriptor: | Selenoprotein W | Authors: | Aachmann, F.L, Fomenko, D.E, Soragni, A, Gladyshev, V.N, Dikiy, A. | Deposit date: | 2006-10-27 | Release date: | 2006-11-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins J.Biol.Chem., 282, 2007
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2O1U
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![BU of 2o1u by Molmil](/molmil-images/mine/2o1u) | Structure of full length GRP94 with AMP-PNP bound | Descriptor: | Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | Deposit date: | 2006-11-29 | Release date: | 2007-10-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
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2O1T
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2O9L
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![BU of 2o9l by Molmil](/molmil-images/mine/2o9l) | AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element | Descriptor: | 5'-D(*GP*AP*AP*AP*CP*GP*TP*GP*CP*CP*AP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*GP*CP*AP*CP*GP*TP*TP*TP*C)-3', RNA polymerase sigma factor RpoN | Authors: | Doucleff, M, Pelton, J.G, Lee, P.S, Wemmer, D.E. | Deposit date: | 2006-12-13 | Release date: | 2007-07-17 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis of DNA recognition by the alternative sigma-factor, sigma54. J.Mol.Biol., 369, 2007
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2OA6
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![BU of 2oa6 by Molmil](/molmil-images/mine/2oa6) | Aristolochene synthase from Aspergillus terreus complexed with pyrophosphate | Descriptor: | Aristolochene synthase, BETA-MERCAPTOETHANOL, GLYCEROL, ... | Authors: | Shishova, E.Y, Di Costanzo, L, Cane, D.E, Christianson, D.W. | Deposit date: | 2006-12-15 | Release date: | 2007-01-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate Biochemistry, 46, 2007
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2O1V
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![BU of 2o1v by Molmil](/molmil-images/mine/2o1v) | Structure of full length GRP94 with ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION | Authors: | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | Deposit date: | 2006-11-29 | Release date: | 2007-10-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
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