2R4B

ErbB4 kinase domain complexed with a thienopyrimidine inhibitor

Summary for 2R4B

• Entry DOI: 10.2210/pdb2r4b/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-4, N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: erb, kinase, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphorylation, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein. ERBB4 intracellular domain: Nucleus: Q15303
• Total number of polymer chains: 2
• Total formula weight: 73935.01

Authors

Shewchuk, L.M.,Uehling, D.E. (deposition date: 2007-08-31, release date: 2008-03-18, Last modification date: 2023-08-30)

• Primary citation: Wood, E.R.,Shewchuk, L.M.,Ellis, B.,Brignola, P.,Brashear, R.L.,Caferro, T.R.,Dickerson, S.H.,Dickson, H.D.,Donaldson, K.H.,Gaul, M.,Griffin, R.J.,Hassell, A.M.,Keith, B.,Mullin, R.,Petrov, K.G.,Reno, M.J.,Rusnak, D.W.,Tadepalli, S.M.,Ulrich, J.C.,Wagner, C.D.,Vanderwall, D.E.,Waterson, A.G.,Williams, J.D.,White, W.L.,Uehling, D.E.; 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.; Proc.Natl.Acad.Sci.Usa, 105:2773-2778, 2008; PubMed: 18287036; DOI: 10.1073/pnas.0708281105

Experimental method

X-RAY DIFFRACTION (2.4 Å)