2R4B
ErbB4 kinase domain complexed with a thienopyrimidine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Receptor tyrosine-protein kinase erbB-4 | polymer | 321 | 36553.6 | 2 | UniProt (Q15303) Pfam (PF07714) In PDB | Homo sapiens (human) | p180erbB4, Tyrosine kinase-type cell surface receptor HER4 |
2 | A, B | N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | non-polymer | 413.9 | 2 | Chemie (GW7) | |||
3 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, B: 690 - 999 (UniProt: Q15303)
PDB | External Database | Details |
---|---|---|
Met 679 | - | expression tag |
Lys 680 | - | expression tag |
Lys 681 | - | expression tag |
Gly 682 | - | expression tag |
His 683 | - | expression tag |
His 684 | - | expression tag |
His 685 | - | expression tag |
His 686 | - | expression tag |
His 687 | - | expression tag |
His 688 | - | expression tag |
Gly 689 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73107.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 827.8 | |
All* | Total formula weight | 73935.0 |