2R4B

ErbB4 kinase domain complexed with a thienopyrimidine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor tyrosine-protein kinase erbB-4	polymer	321	36553.6	2	UniProt (Q15303) Pfam (PF07714)	Homo sapiens (human)	p180erbB4, Tyrosine kinase-type cell surface receptor HER4
2	C, D (A, B)	N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine	non-polymer		413.9	2	Chemie (GW7)
3	E, F (A, B)	water	water		18.0	137	Chemie (HOH)

Sequence modifications

A, B: 690 - 999 (UniProt: Q15303)

PDB	External Database	Details
Met 679	-	expression tag
Lys 680	-	expression tag
Lys 681	-	expression tag
Gly 682	-	expression tag
His 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
Gly 689	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73107.2
Non-Polymers*	Number of molecules	2
	Total formula weight	827.8
All*	Total formula weight	73935.0

*Water molecules are not included.