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2QS3

Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution

Summary for 2QS3
Entry DOI10.2210/pdb2qs3/pdb
Related1TXF 2F34 2F35 2F36 2QS1 2QS2 2QS4
DescriptorGlutamate receptor, ionotropic kainate 1, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordsmembrane protein, cell junction, glycoprotein, ion transport, ionic channel, phosphorylation, postsynaptic cell membrane, receptor, rna editing, synapse, transmembrane, transport
Biological sourceRattus norvegicus (rat)
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Cellular locationCell membrane; Multi-pass membrane protein: P22756
Total number of polymer chains2
Total formula weight59829.42
Authors
Alushin, G.M.,Jane, D.E.,Mayer, M.L. (deposition date: 2007-07-30, release date: 2008-08-05, Last modification date: 2023-08-30)
Primary citationDargan, S.L.,Clarke, V.R.,Alushin, G.M.,Sherwood, J.L.,Nistico, R.,Bortolotto, Z.A.,Ogden, A.M.,Bleakman, D.,Doherty, A.J.,Lodge, D.,Mayer, M.L.,Fitzjohn, S.M.,Jane, D.E.,Collingridge, G.L.
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Neuropharmacology, 56:121-130, 2009
Cited by
PubMed: 18789344
DOI: 10.1016/j.neuropharm.2008.08.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.76 Å)
Structure validation

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